Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.65 |
| ▸ | F13A1 | P00488 | 1/20 | 0.65 |
| ▸ | GAA | P10253 | 2/20 | 0.58 |
| ▸ | GFER | P55789 | 2/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | ESRRB | O95718 | 2/20 | 0.58 |
| ▸ | ESRRG | P62508 | 2/20 | 0.58 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.52 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.50 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.50 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.50 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.50 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14370357 | 0.88 | KDM4E (0.69) | KDM4EF13A1GAAGFERNPC1 | |
| SCHEMBL2379821 | 0.85 | KDM4E (0.65) | KDM4EF13A1GAAGFERNPC1 | |
| SCHEMBL4161209 | 0.85 | ESRRB (0.77) | KDM4EF13A1GAAGFERNPC1 | |
| SCHEMBL5574769 | 0.85 | LMNA (0.66) | GAAGFERNPC1CYP1A2CYP2D6 | |
| SCHEMBL28747980 | 0.85 | KDM4E (0.65) | KDM4EF13A1GAAGFERNPC1 | |
| SCHEMBL23700596 | 0.83 | KDM4E (0.62) | KDM4EF13A1GAAGFERNPC1 | |
| SCHEMBL20052590 | 0.83 | LMNA (0.47) | KDM4EF13A1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL21377225 | 0.83 | KDM4E (0.62) | KDM4EF13A1GAAGFERNPC1 | |
| SCHEMBL6425050 | 0.83 | KDM4E (0.62) | KDM4EF13A1GAAGFERNPC1 | |
| SCHEMBL7842536 | 0.83 | KDM4E (0.68) | KDM4EF13A1GAAGFERNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1212056-B1 | METHODS AND COMPOSITIONS FOR BISUBSTRATE INHIBITORS OF ACETYLTRANSFERASES | US GOV HEALTH & HUMAN SERV (US) | 2005-12-07 | — | — | EP | claimed |
| EP-1212056-A1 | METHODS AND COMPOSITIONS FOR BISUBSTRATE INHIBITORS OF ACETYLTRANSFERASES | The Government of the United States of America, as represented by the Secretary, Department of Health and Human Services (US) | 2002-06-12 | — | — | EP | claimed |
| US-20020002144-A1 | Methods and compositions for bisubstrate inhibitors of acetyltransferases | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, DEPARTMENT OF HEALTH & HUMAN SERVICES (US) | 2002-01-03 | — | — | US | claimed |
| WO-2001012185-A1 | METHODS AND COMPOSITIONS FOR BISUBSTRATE INHIBITORS OF ACETYLTRANSFERASES | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2001-02-22 | — | — | WO | claimed |
| EP-2341915-B1 | PHOSPHORYLATED DENDRIMERS AS ANTIINFLAMMATORY DRUGS | CENTRE NAT RECH SCIENT (FR) | 2019-03-20 | — | — | EP | disclosed |
| EP-2341915-B1 | PHOSPHORYLATED DENDRIMERS AS ANTIINFLAMMATORY DRUGS | CENTRE NAT RECH SCIENT (FR) | 2019-03-20 | — | — | EP | disclosed |
| US-10106565-B2 | Phosphorylated dendrimers as antiinflammatory drugs | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2018-10-23 | — | — | US | disclosed |
| US-20130336997-A1 | PHOSPHORYLATED DENDRIMERS AS ANTIINFLAMMATORY DRUGS | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2013-12-19 | — | — | US | disclosed |
| EP-2341915-A1 | PHOSPHORYLATED DENDRIMERS AS ANTIINFLAMMATORY DRUGS | Centre National de la Recherche Scientifique (FR) | 2011-07-13 | — | — | EP | disclosed |
| US-20100173871-A1 | PHOSPHORYLATED DENDRIMERS AS ANTIINFLAMMATORY DRUGS | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2010-07-08 | — | — | US | disclosed |
| US-20100173871-A1 | PHOSPHORYLATED DENDRIMERS AS ANTIINFLAMMATORY DRUGS | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2010-07-08 | — | — | US | disclosed |
| WO-2010013086-A1 | PHOSPHORYLATED DENDRIMERS AS ANTIINFLAMMATORY DRUGS | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2010-02-04 | — | — | WO | disclosed |
| EP-1212056-B1 | METHODS AND COMPOSITIONS FOR BISUBSTRATE INHIBITORS OF ACETYLTRANSFERASES | US GOV HEALTH & HUMAN SERV (US) | 2005-12-07 | — | — | EP | disclosed |
| EP-1212056-A1 | METHODS AND COMPOSITIONS FOR BISUBSTRATE INHIBITORS OF ACETYLTRANSFERASES | The Government of the United States of America, as represented by the Secretary, Department of Health and Human Services (US) | 2002-06-12 | — | — | EP | disclosed |
| US-20020002144-A1 | Methods and compositions for bisubstrate inhibitors of acetyltransferases | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, DEPARTMENT OF HEALTH & HUMAN SERVICES (US) | 2002-01-03 | — | — | US | disclosed |
| WO-2001012185-A1 | METHODS AND COMPOSITIONS FOR BISUBSTRATE INHIBITORS OF ACETYLTRANSFERASES | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2001-02-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10106565-B2 | Phosphorylated dendrimers as antiinflammatory drugs | DUSP6, DUSP10, PTMS | KDM4E 3952/4885F13A1 2614/4885GAA 2018/4885 |
| US-20130336997-A1 | PHOSPHORYLATED DENDRIMERS AS ANTIINFLAMMATORY DRUGS | DUSP6, DUSP10, PTMS | KDM4E 3952/4885F13A1 2614/4885GAA 2018/4885 |
| US-20100173871-A1 | PHOSPHORYLATED DENDRIMERS AS ANTIINFLAMMATORY DRUGS | CD14, DUSP3, IRAK3 | KDM4E 4254/4885F13A1 2767/4885GAA 1845/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.