Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.49 |
| ▸ | VCP | P55072 | 2/20 | 0.48 |
| ▸ | ABCG2 | Q9UNQ0 | 7/20 | 0.48 |
| ▸ | ABCB1 | P08183 | 6/20 | 0.48 |
| ▸ | ABCC1 | P33527 | 3/20 | 0.48 |
| ▸ | CTSK | P43235 | 2/20 | 0.47 |
| ▸ | CTSS | P25774 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | TTK | P33981 | 1/20 | 0.46 |
| ▸ | CTSL | P07711 | 1/20 | 0.46 |
| ▸ | CTSB | P07858 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | MERTK | Q12866 | 1/20 | 0.44 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13729350 | 0.89 | JAK2 (0.56) | SYKVCPABCG2ABCB1ABCC1 | |
| SCHEMBL21914834 | 0.85 | CTSK (0.58) | SYKABCG2ABCB1ABCC1CTSK | |
| SCHEMBL13086647 | 0.82 | VSIR (0.43) | SYKVCPABCG2ABCB1ABCC1 | |
| SCHEMBL4486162 | 0.81 | KCNH2 (0.58) | SYKABCG2JAK2KCNH2SCN5A | |
| SCHEMBL13681538 | 0.80 | KDR (0.50) | SYKVCPABCG2ABCB1ABCC1 | |
| SCHEMBL21915358 | 0.79 | CTSK (0.54) | SYKVCPABCG2ABCB1CTSK | |
| SCHEMBL248043 | 0.79 | PDE4B (0.49) | SYKABCG2ABCB1ABCC1CTSK | |
| SCHEMBL12158707 | 0.79 | JAK2 (0.59) | SYKABCG2ABCB1ABCC1CTSK | |
| SCHEMBL24490452 | 0.78 | ABCG2 (0.59) | SYKABCG2ABCB1CTSKCTSS | |
| SCHEMBL24490436 | 0.78 | ABCG2 (0.59) | SYKABCG2ABCB1CTSKCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101993420-A | Preparation method of 4-[(4,6-dihydroxyl-2-pyrimidinyl)amino] cyanobenzene | ZHEJIANG JIUZHOU PHARM CO LTD | 2011-03-30 | — | — | CN | claimed |
| EP-2702045-B1 | NOVEL PROCESS FOR THE PREPARATION OF ETRAVIRINE | MYLAN LABORATORIES LTD (IN) | 2017-10-18 | — | — | EP | disclosed |
| US-20150336900-A1 | Process for the Synthesis of Etravirine and Its Intermediates | BIOPHORE INDIA PHARMACEUTICALS PVT. LTD. (IN) | 2015-11-26 | — | — | US | disclosed |
| US-20150336900-A1 | Process for the Synthesis of Etravirine and Its Intermediates | BIOPHORE INDIA PHARMACEUTICALS PVT. LTD. (IN) | 2015-11-26 | — | — | US | disclosed |
| US-9006243-B2 | HIV inhibiting 6-substituted pyrimidines | JANSSEN R&D IRELAND (IE) | 2015-04-14 | — | — | US | disclosed |
| US-9006243-B2 | HIV inhibiting 6-substituted pyrimidines | JANSSEN R&D IRELAND (IE) | 2015-04-14 | — | — | US | disclosed |
| EP-1853567-B1 | HIV INHIBITING 2-(4-CYANOPHENYLAMINO) PYRIMIDINE OXIDE DERIVATIVES | JANSSEN R & D IRELAND (IE) | 2014-12-31 | — | — | EP | disclosed |
| EP-2342186-B1 | PROCESS FOR SYNTHESIS OF ETRAVIRINE | EMCURE PHARMACEUTICALS LTD (IN) | 2014-09-17 | — | — | EP | disclosed |
| WO-2014068588-A2 | PROCESS FOR THE SYNTHESIS OF ETRAVIRINE AND ITS INTERMEDIATES | BIOPHORE INDIA PHARMACEUTICALS PVT. LTD. (IN) | 2014-05-08 | — | — | WO | disclosed |
| EP-2702045-A1 | NOVEL PROCESS FOR THE PREPARATION OF ETRAVIRINE | Mylan Laboratories, Limited (IN) | 2014-03-05 | — | — | EP | disclosed |
| CN-101993420-A | Preparation method of 4-[(4,6-dihydroxyl-2-pyrimidinyl)amino] cyanobenzene | ZHEJIANG JIUZHOU PHARM CO LTD | 2011-03-30 | — | — | CN | disclosed |
| CN-101993420-A | Preparation method of 4-[(4,6-dihydroxyl-2-pyrimidinyl)amino] cyanobenzene | ZHEJIANG JIUZHOU PHARM CO LTD | 2011-03-30 | — | — | CN | disclosed |
| WO-2010150279-A2 | PROCESS FOR SYNTHESIS OF DIARYLPYRIMIDINE NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR | EMCURE PHARMACEUTICALS LIMITED (IN) | 2010-12-29 | — | — | WO | disclosed |
| US-20100016317-A1 | HIV INHIBITING 6-SUBSTITUTED PYRIMIDINES | JANSSEN SCIENCES IRELAND UC (IE) | 2010-01-21 | — | — | US | disclosed |
| US-20100016317-A1 | HIV INHIBITING 6-SUBSTITUTED PYRIMIDINES | JANSSEN SCIENCES IRELAND UC (IE) | 2010-01-21 | — | — | US | disclosed |
| US-20090124644-A1 | HIV INHIBITING 2-(4-CYANOPHENYLAMINO) PYRIMIDINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-05-14 | — | — | US | disclosed |
| US-20090124644-A1 | HIV INHIBITING 2-(4-CYANOPHENYLAMINO) PYRIMIDINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-05-14 | — | — | US | disclosed |
| US-20080194602-A1 | Hiv Inhibiting 2-(4-Cyanophenylamino) Pyrimidine Oxide Derivatives | SONY CORPORATION (JP) | 2008-08-14 | — | — | US | disclosed |
| US-20080194602-A1 | Hiv Inhibiting 2-(4-Cyanophenylamino) Pyrimidine Oxide Derivatives | SONY CORPORATION (JP) | 2008-08-14 | — | — | US | disclosed |
| WO-2008080964-A1 | HIV INHIBITING 6-SUBSTITUTED PYRIMIDINES | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2008-07-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150336900-A1 | Process for the Synthesis of Etravirine and Its Intermediates | CYP3A4, CYP3A5, ERN1 | SYK 4358/4885VCP 1196/4885ABCG2 1685/4885 |
| US-20080194602-A1 | Hiv Inhibiting 2-(4-Cyanophenylamino) Pyrimidine Oxide Derivatives | RTF2, SAMHD1, NUDT1 | SYK 4528/4885VCP 2024/4885ABCG2 616/4885 |
| US-20100016317-A1 | HIV INHIBITING 6-SUBSTITUTED PYRIMIDINES | CCR5, CTR9, NR1H3 | SYK 4347/4885VCP 4080/4885ABCG2 491/4885 |
| US-20090124644-A1 | HIV INHIBITING 2-(4-CYANOPHENYLAMINO) PYRIMIDINE DERIVATIVES | NR4A3, NR4A1, NR4A2 | SYK 2773/4885VCP 3895/4885ABCG2 659/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.