SCHEMBL21928602

SCHEMBL21928602

Cc1ccc(-c2ccc3c(c2)c2ccccc2n3-c2cc(-c3ccc(C#N)cc3)c(-n3c4ccccc4c4cc(-c5ccccc5)ccc43)cn2)cc1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGER4 P35408 2/20 0.38
MAPKAPK2 P49137 1/20 0.37
METAP2 P50579 1/20 0.35
KDM1A O60341 4/20 0.35
GABRA1 P14867 1/20 0.34
GABRG2 P18507 1/20 0.34
GABRB3 P28472 1/20 0.34
GABRA5 P31644 1/20 0.34
GABRA3 P34903 1/20 0.34
KDM4E B2RXH2 1/20 0.34
HPGD P15428 1/20 0.34
PPARG P37231 1/20 0.34
NCOA2 Q15596 1/20 0.34
NCOA1 Q15788 1/20 0.34
NPSR1 Q6W5P4 1/20 0.34
NCOA3 Q9Y6Q9 1/20 0.34
ADORA2A P29274 1/20 0.34
ADORA1 P30542 1/20 0.34
PIK3CD O00329 1/20 0.34
PIK3CA P42336 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21929022 0.95 PTGER4 (0.39) PTGER4METAP2KDM1AGABRA1GABRG2
SCHEMBL21931712 0.93 MAPKAPK2 (0.42) MAPKAPK2KDM1AKDM4EPIK3CDPIK3CA
SCHEMBL21929233 0.93 PTGER4 (0.40) PTGER4METAP2GABRA1GABRG2GABRB3
SCHEMBL21931685 0.92 KIT (0.36) PTGER4GABRA1GABRG2GABRB3GABRA5
SCHEMBL21929038 0.92 PTGER4 (0.39) PTGER4METAP2KDM1AGABRA1GABRG2
SCHEMBL21928605 0.92 PTGER4 (0.39) PTGER4MAPKAPK2KDM1AKDM4EPIK3CD
SCHEMBL23098054 0.92 PTGER4 (0.41) PTGER4METAP2KDM1AKDM4EHPGD
SCHEMBL21928541 0.92 GABRA1 (0.40) PTGER4METAP2KDM1AGABRA1GABRG2
SCHEMBL21929040 0.91 PTGER4 (0.39) PTGER4MAPKAPK2METAP2KDM1AKDM4E
SCHEMBL21928413 0.89 GRM5 (0.39) PTGER4GABRA1GABRG2GABRB3GABRA5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220388960-A1 ORGANIC MOLECULES FOR USE IN LIGHT-EMITTING DEVICES CYNORA GMBH (DE) 2022-12-08 US disclosed
US-20200136054-A1 ORGANIC MOLECULES FOR USE IN ORGANIC OPTOELECTRONIC DEVICES SAMSUNG DISPLAY CO., LTD. (KR) 2020-04-30 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200136054-A1 ORGANIC MOLECULES FOR USE IN ORGANIC OPTOELECTRONIC DEVICES OR10J3, OGFR, OR51E2 PTGER4 1018/4885MAPKAPK2 3575/4885METAP2 3058/4885
US-20220388960-A1 ORGANIC MOLECULES FOR USE IN LIGHT-EMITTING DEVICES ALDH1A2, AOX1, CYBA PTGER4 1294/4885MAPKAPK2 3250/4885METAP2 1141/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.