SCHEMBL2193164

SCHEMBL2193164

Clc1ccc(-c2ccccc2CN2CCN(CC=Cc3ccccc3)CC2)cc1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.61
LMNA P02545 6/20 0.53
HTR7 P34969 2/20 0.52
MAPT P10636 3/20 0.50
GAA P10253 3/20 0.48
TSHR P16473 3/20 0.48
USP2 O75604 1/20 0.47
CYP3A4 P08684 2/20 0.47
HIF1A Q16665 2/20 0.47
MAPK1 P28482 2/20 0.47
CYP1A2 P05177 1/20 0.47
CYP2D6 P10635 1/20 0.47
CYP2C9 P11712 1/20 0.47
GMNN O75496 1/20 0.47
ABCB11 O95342 1/20 0.47
CHRM2 P08172 1/20 0.47
CHRM4 P08173 1/20 0.47
HTR1A P08908 1/20 0.47
CHRM5 P08912 1/20 0.47
ADRA2A P08913 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1137923 0.85 HTR7 (0.54) ALDH1A1LMNAHTR7MAPTGAA
SCHEMBL588394 0.81 SIGMAR1 (0.67) ALDH1A1LMNAHTR7MAPTGAA
Hydrochloric Acid SCHEMBL587708 0.80 SIGMAR1 (0.65) ALDH1A1LMNAHTR7SIGMAR1BCL2
SCHEMBL1138132 0.78 HTR7 (0.47) ALDH1A1LMNAHTR7USP2SLC6A2
SCHEMBL1138135 0.77 HTR7 (0.60) ALDH1A1LMNAHTR7MAPTGAA
SCHEMBL2194377 0.77 HTR7 (0.63) ALDH1A1LMNAHTR7MAPTGAA
SCHEMBL16226424 0.77 SMN1; SMN2 (0.62) ALDH1A1LMNAGAATSHRUSP2
SCHEMBL16226425 0.77 SMN1; SMN2 (0.62) ALDH1A1LMNAGAATSHRUSP2
SCHEMBL1138092 0.77 HTR7 (0.54) ALDH1A1HTR7BCL2BAK1
SCHEMBL11843454 0.77 ALDH1A1 (0.60) ALDH1A1LMNAMAPTGAATSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110172425-A1 NOVEL WATER BASED PROCESS FOR THE PREPARATION OF SUBSTITUTED DIPHENYLMETHYL PIPERAZINES CALYX CHEMICALS AND PHARMACEUTICALS PVT. LTD. (IN) 2011-07-14 US disclosed
WO-2010046908-A2 NOVEL WATER BASED PROCESS FOR THE PREPARATION OF SUBSTITUTED DIPHENYLMETHYL PIPERAZINES CALYX CHEMICALS AND PHARMACEUTICALS PVT. LTD. (IN) 2010-04-29 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110172425-A1 NOVEL WATER BASED PROCESS FOR THE PREPARATION OF SUBSTITUTED DIPHENYLMETHYL PIPERAZINES ALK, WIZ, HACL2 ALDH1A1 310/4885LMNA 2353/4885HTR7 1254/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.