Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | ERN1 | O75460 | 6/20 | 0.35 |
| ▸ | POLB | P06746 | 3/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CASP6 | P55212 | 1/20 | 0.33 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | UNG | P13051 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14953740 | 0.81 | CYP19A1 (0.49) | CYP19A1ERN1POLBL3MBTL1KDM4E | |
| SCHEMBL29266725 | 0.65 | CYP3A4 (0.35) | CYP19A1ERN1POLBL3MBTL1KDM4E | |
| SCHEMBL12491809 | 0.64 | ERN1 (0.54) | CYP19A1ERN1POLBL3MBTL1KDM4E | |
| SCHEMBL14266405 | 0.64 | THRB (0.39) | ERN1POLBL3MBTL1KDM4ECASP6 | |
| Allylamine SCHEMBL29216101 | 0.63 | PTGDR2 (0.38) | CYP19A1ERN1HTTALDH1A1UNG | |
| SCHEMBL1175576 | 0.63 | TDP1 (0.58) | CYP19A1ERN1POLBL3MBTL1KDM4E | |
| SCHEMBL21938917 | 0.63 | CDK4 (0.38) | CYP19A1ERN1POLBL3MBTL1KDM4E | |
| SCHEMBL243902 | 0.63 | ERN1 (0.52) | CYP19A1ERN1POLBL3MBTL1KDM4E | |
| SCHEMBL28385475 | 0.63 | ERN1 (0.57) | ERN1POLBL3MBTL1CASP6CTDSP1 | |
| SCHEMBL4918747 | 0.63 | ALDH1A1 (0.52) | ERN1POLBL3MBTL1KDM4ECTDSP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11034647-B2 | Histone acetyltransferase activators and uses thereof | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2021-06-15 | — | — | US | disclosed |
| US-20200115325-A1 | HISTONE ACETYLTRANSFERASE ACTIVATORS AND USES THEREOF | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2020-04-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11034647-B2 | Histone acetyltransferase activators and uses thereof | EP300, KAT2A, NAA40 | CYP19A1 4556/4885ERN1 2413/4885POLB 2276/4885 |
| US-20200115325-A1 | HISTONE ACETYLTRANSFERASE ACTIVATORS AND USES THEREOF | EP300, KAT2A, NAA40 | CYP19A1 4556/4885ERN1 2413/4885POLB 2276/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.