Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.33 |
| ▸ | HPGD | P15428 | 4/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.31 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | KHK | P50053 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21941081 | 0.78 | AKT1 (0.32) | — | |
| SCHEMBL21940502 | 0.75 | CTSS (0.38) | ALDH1A1KDM4EHPGDHSD17B10TDP1 | |
| SCHEMBL21940294 | 0.72 | LRRK2 (0.44) | ALDH1A1KDM4EHPGDHSD17B10KHK | |
| SCHEMBL21940791 | 0.72 | LRRK2 (0.44) | ALDH1A1KDM4EHPGDHSD17B10KHK | |
| SCHEMBL21940293 | 0.70 | KDM4E (0.44) | ALDH1A1KDM4EHPGDHSD17B10MEN1 | |
| SCHEMBL21940802 | 0.70 | KDM4E (0.44) | ALDH1A1KDM4EHPGDHSD17B10MEN1 | |
| SCHEMBL21940582 | 0.70 | KDM4E (0.44) | ALDH1A1KDM4EHPGDHSD17B10MEN1 | |
| SCHEMBL21940800 | 0.70 | KDM4E (0.44) | ALDH1A1KDM4EHPGDHSD17B10MEN1 | |
| SCHEMBL21941078 | 0.68 | KDM4E (0.38) | ALDH1A1KDM4EHPGDKHK | |
| SCHEMBL21940787 | 0.67 | CHRM4 (0.35) | ALDH1A1KDM4EHPGDHSD17B10RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3423445-B1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF FIBROSIS | GALAPAGOS NV (BE) | 2020-04-01 | — | — | EP | disclosed |