SCHEMBL2194066

SCHEMBL2194066

CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)[C@@H](C)O)C(=O)N[C@H]([C]=O)CCCNC(=N)N

nearest known ligand 0.63

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
NPY4R P50391 16/20 0.63
NPY1R P25929 10/20 0.63
NPY5R Q15761 9/20 0.63
NPY2R P49146 6/20 0.63
KISS1R Q969F8 3/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30974526 0.86 KISS1R (0.63) NPY4RNPY1RNPY5RNPY2RKISS1R
SCHEMBL31031550 0.85 NPY4R (0.74) NPY4RNPY1RNPY5RNPY2R
SCHEMBL2182662 0.83 NPY4R (0.70) NPY4RNPY1RNPY5RNPY2R
SCHEMBL30087257 0.83 NPY4R (0.59) NPY4RNPY1RNPY5RNPY2RKISS1R
SCHEMBL2185394 0.83 NPY4R (0.58) NPY4RNPY1RNPY5RNPY2R
SCHEMBL2192841 0.82 NPY4R (0.60) NPY4RNPY1RNPY5RNPY2R
SCHEMBL16507929 0.82 NPY4R (0.63) NPY4RNPY1RNPY5RNPY2RKISS1R
SCHEMBL29638064 0.82 NPY4R (0.74) NPY4RNPY1RNPY5RNPY2R
SCHEMBL30087253 0.82 NPY4R (0.67) NPY4RNPY1RNPY5RNPY2R
SCHEMBL30669464 0.82 NPY4R (0.62) NPY4RNPY1RNPY5RNPY2RKISS1R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9173951-B2 Carbohydrate-based drug delivery polymers and conjugates thereof NEKTAR THERAPEUTICS (US) 2015-11-03 US disclosed
US-20150051371-A1 CARBOHYDRATE-BASED DRUG DELIVERY POLYMERS AND CONJUGATES THEREOF NEKTAR THERAPEUTICS (US) 2015-02-19 US disclosed
US-8680263-B2 Carbohydrate-based drug delivery polymers and conjugates thereof NEKTAR THERAPEUTICS (US) 2014-03-25 US disclosed
US-20110171716-A1 CARBOHYDRATE-BASED DRUG DELIVERY POLYMERS AND CONJUGATES THEREOF NEKTAR THERAPEUTICS (US) 2011-07-14 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110171716-A1 CARBOHYDRATE-BASED DRUG DELIVERY POLYMERS AND CONJUGATES THEREOF STT3B, STT3A, DDOST NPY4R 2480/4885NPY1R 3329/4885NPY5R 3577/4885
US-20150051371-A1 CARBOHYDRATE-BASED DRUG DELIVERY POLYMERS AND CONJUGATES THEREOF STT3B, STT3A, DDOST NPY4R 2480/4885NPY1R 3329/4885NPY5R 3577/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.