Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Sulfathiazole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.97 |
| ▸ | LMNA | P02545 | 4/20 | 0.97 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.97 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.97 |
| ▸ | EDNRA | P25101 | 1/20 | 0.97 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.97 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.97 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.97 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.97 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.70 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.63 |
| ▸ | PKM | P14618 | 5/20 | 0.62 |
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | ATM | Q13315 | 1/20 | 0.59 |
| ▸ | AKT1 | P31749 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | PPIA | P62937 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | AURKA | O14965 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfathiazole SCHEMBL30130508 | 0.98 | ALDH1A1 (1.00) | ALDH1A1LMNAKDM4ECYP2C9EDNRA | |
| Sulfathiazole SCHEMBL94165 | 0.98 | ALDH1A1 (1.00) | ALDH1A1LMNAKDM4ECYP2C9EDNRA | |
| Sulfathiazole SCHEMBL468436 | 0.97 | ALDH1A1 (0.97) | ALDH1A1LMNAKDM4ECYP2C9EDNRA | |
| Sulfathiazole SCHEMBL18425505 | 0.97 | ALDH1A1 (0.97) | ALDH1A1LMNAKDM4ECYP2C9EDNRA | |
| Sulfathiazole SCHEMBL11623928 | 0.95 | ALDH1A1 (0.94) | ALDH1A1LMNAKDM4ECYP2C9EDNRA | |
| Sulfathiazole SCHEMBL11626630 | 0.95 | ALDH1A1 (0.94) | ALDH1A1LMNAKDM4ECYP2C9EDNRA | |
| SCHEMBL848949 | 0.94 | ALDH1A1 (0.91) | ALDH1A1LMNAKDM4ECYP2C9EDNRA | |
| Sulfathiazole SCHEMBL28079171 | 0.94 | ALDH1A1 (0.91) | ALDH1A1LMNAKDM4ECYP2C9EDNRA | |
| Sulfathiazole SCHEMBL28264889 | 0.93 | ALDH1A1 (0.89) | ALDH1A1LMNAKDM4ECYP2C9EDNRA | |
| Sulfadiazine SCHEMBL28117247 | 0.90 | LMNA (0.84) | ALDH1A1LMNAKDM4ECYP2C9EDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113559264-A | Methods of treating microbial infections including mastitis | 罗达制药公司 | 2021-10-29 | — | — | CN | claimed |
| CN-113144197-A | Method of treating topical microbial infections | 罗达制药公司 | 2021-07-23 | — | — | CN | claimed |
| CN-105492005-A | Methods of treating microbial infections including mastitis | LUODA PHARMA PTY LTD | 2016-04-13 | — | — | CN | claimed |
| CN-105492004-A | Method of treating topical microbial infections | LUODA PHARMA PTY LTD | 2016-04-13 | — | — | CN | claimed |
| CN-102209561-B | Elastomeric article having a broad spectrum antimicrobial agent and method of making | BACTERIN INTERNAT INC | 2014-08-06 | — | — | CN | claimed |
| CN-102209561-A | Elastomeric article having a broad spectrum antimicrobial agent and method of making | BACTERIN INTERNAT INC | 2011-10-05 | — | — | CN | claimed |
| EP-2344215-A2 | ELASTOMERIC ARTICLE HAVING A BROAD SPECTRUM ANTIMICROBIAL AGENT AND METHOD OF MAKING | Bacterin International, Inc. (US) | 2011-07-20 | — | — | EP | claimed |
| US-20110171321-A1 | ELASTOMERIC ARTICLE HAVING A BROAD SPECTRUM ANTIMICROBIAL AGENT AND METHOD OF MAKING | X-SPINE SYSTEMS, INC. | 2011-07-14 | — | — | US | claimed |
| WO-2010030374-A2 | ELASTOMERIC ARTICLE HAVING A BROAD SPECTRUM ANTIMICROBIAL AGENT AND METHOD OF MAKING | BACTERIN INTERNATIONAL, INC. (US) | 2010-03-18 | — | — | WO | claimed |
| US-20230019159-A1 | RAPID DRUG DISCOVERY METHODS FOR PATHOGEN INACTIVATION | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY | 2023-01-19 | — | — | US | disclosed |
| US-11382328-B2 | Rapid drug discovery methods for pathogen inactivation | ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) | 2022-07-12 | — | — | US | disclosed |
| CN-113559264-A | Methods of treating microbial infections including mastitis | 罗达制药公司 | 2021-10-29 | — | — | CN | disclosed |
| CN-113144197-A | Method of treating topical microbial infections | 罗达制药公司 | 2021-07-23 | — | — | CN | disclosed |
| CN-111905104-A | Method of treating topical microbial infections | 罗达制药公司 | 2020-11-10 | — | — | CN | disclosed |
| US-20110171321-A1 | ELASTOMERIC ARTICLE HAVING A BROAD SPECTRUM ANTIMICROBIAL AGENT AND METHOD OF MAKING | X-SPINE SYSTEMS, INC. | 2011-07-14 | — | — | US | disclosed |
| CN-101472560-B | Pharmaceutical composition for treating burn and preparation method thereof | RASNETSOV LEV DAVIDOVICH | 2011-03-23 | — | — | CN | disclosed |
| WO-2010030374-A2 | ELASTOMERIC ARTICLE HAVING A BROAD SPECTRUM ANTIMICROBIAL AGENT AND METHOD OF MAKING | BACTERIN INTERNATIONAL, INC. (US) | 2010-03-18 | — | — | WO | disclosed |
| CN-101472560-A | Pharmaceutical composition for treating burn and preparation method thereof | RASNETSOV LEV DAVIDOVICH (RU) | 2009-07-01 | — | — | CN | disclosed |
| EP-2030612-A1 | PHARMACEUTICAL COMPOSITION FOR TREATING BURNS (VARIANTS) AND A METHOD FOR THE PRODUCTION THEREOF (VARIANTS) | Rasnetsov, Lev Davidovich (RU) | 2009-03-04 | — | — | EP | disclosed |
| US-4020150-A | SYSTEMIC INFECTIONS, TUMORS | Ebert, Michael (US) | 1977-04-26 | — | — | US | disclosed |