Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Sulfathiazole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.97 |
| ▸ | LMNA | P02545 | 4/20 | 0.97 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.97 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.97 |
| ▸ | EDNRA | P25101 | 1/20 | 0.97 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.97 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.97 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.97 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.97 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.70 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.63 |
| ▸ | PKM | P14618 | 5/20 | 0.62 |
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | ATM | Q13315 | 1/20 | 0.59 |
| ▸ | AKT1 | P31749 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | PPIA | P62937 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | AURKA | O14965 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfathiazole SCHEMBL11626630 | 0.98 | ALDH1A1 (0.94) | ALDH1A1LMNAKDM4ECYP2C9EDNRA | |
| Sulfathiazole SCHEMBL30130508 | 0.98 | ALDH1A1 (1.00) | ALDH1A1LMNAKDM4ECYP2C9EDNRA | |
| Sulfathiazole SCHEMBL94165 | 0.98 | ALDH1A1 (1.00) | ALDH1A1LMNAKDM4ECYP2C9EDNRA | |
| Sulfathiazole SCHEMBL18425505 | 0.97 | ALDH1A1 (0.97) | ALDH1A1LMNAKDM4ECYP2C9EDNRA | |
| Sulfathiazole SCHEMBL2194108 | 0.97 | ALDH1A1 (0.97) | ALDH1A1LMNAKDM4ECYP2C9EDNRA | |
| Sulfathiazole SCHEMBL11623928 | 0.95 | ALDH1A1 (0.94) | ALDH1A1LMNAKDM4ECYP2C9EDNRA | |
| SCHEMBL848949 | 0.94 | ALDH1A1 (0.91) | ALDH1A1LMNAKDM4ECYP2C9EDNRA | |
| Sulfathiazole SCHEMBL28079171 | 0.94 | ALDH1A1 (0.91) | ALDH1A1LMNAKDM4ECYP2C9EDNRA | |
| Sulfathiazole SCHEMBL28264889 | 0.93 | ALDH1A1 (0.89) | ALDH1A1LMNAKDM4ECYP2C9EDNRA | |
| Sulfadiazine SCHEMBL28117247 | 0.90 | LMNA (0.84) | ALDH1A1LMNAKDM4ECYP2C9EDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 122 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119050449-A | Sodium ion battery | 深圳市豪鹏科技股份有限公司 | 2024-11-29 | — | — | CN | claimed |
| CN-114846332-A | Biocide compositions compatible with enzyme biosensors and methods of use thereof | 仪器实验室公司 | 2022-08-02 | — | — | CN | claimed |
| CN-111521712-B | Liquid chromatography analysis method for simultaneously determining contents of 3 sulfonamides and 4 quinolones | 重庆方通动物药业有限公司 | 2022-05-06 | — | — | CN | claimed |
| CN-111474132-B | Rapid detection method for content of micro-plastic in water body and application | 浙江省海洋水产研究所 | 2021-09-07 | — | — | CN | claimed |
| CN-111521712-A | Liquid chromatography analysis method for simultaneously determining contents of 3 sulfonamides and 4 quinolones | 重庆方通动物药业有限公司 | 2020-08-11 | — | — | CN | claimed |
| CN-111474132-A | Rapid detection method for content of micro-plastic in water body and application | 浙江省海洋水产研究所 | 2020-07-31 | — | — | CN | claimed |
| US-9682021-B2 | Substantially non-aqueous foamable petrolatum based pharmaceutical and cosmetic compositions and their uses | FOAMIX PHARMACEUTICALS LTD. (IL) | 2017-06-20 | — | — | US | claimed |
| US-20140248219-A1 | SUBSTANTIALLY NON-AQUEOUS FOAMABLE PETROLATUM BASED PHARMACEUTICAL AND COSMETIC COMPOSITIONS AND THEIR USES | FOAMIX LTD. (IL) | 2014-09-04 | — | — | US | claimed |
| US-8795635-B2 | Substantially non-aqueous foamable petrolatum based pharmaceutical and cosmetic compositions and their uses | FOAMIX LTD. (IL) | 2014-08-05 | — | — | US | claimed |
| EP-2257276-A2 | SUBSTANTIALLY NON-AQUEOUS FOAMABLE PETROLATUM BASED PHARMACEUTICAL AND COSMETIC COMPOSITIONS AND THEIR USES | Foamix Ltd. (IL) | 2010-12-08 | — | — | EP | claimed |
| US-20080260655-A1 | stable, non-alcoholic, non-silicone, foamable carrier compositions comprising petrolatum, foam agent, propellant, | FOAMIX PHARMACEUTICALS LTD. (IL) | 2008-10-23 | — | — | US | claimed |
| US-20080206155-A1 | STABLE NON-ALCOHOLIC FOAMABLE PHARMACEUTICAL EMULSION COMPOSITIONS WITH AN UNCTUOUS EMOLLIENT AND THEIR USES | FOAMIX LTD. | 2008-08-28 | — | — | US | claimed |
| CN-101007032-A | Compound sulfathiazole sodium injection liquid and its preparation method | TIANJIN SHENGJI GROUP CO LTD (CN) | 2007-08-01 | — | — | CN | claimed |
| US-20020188013-A1 | Composition for treatment of malignant tumors | DECHANT RICHARD FREDERICK (US) | 2002-12-12 | — | — | US | claimed |
| EP-0862420-A4 | SYNTHESIS OF DRUG NANOPARTICLES BY SPRAY DRYING | PENN STATE RES FOUND (US) | 1999-11-03 | — | — | EP | claimed |
| EP-0862420-A1 | SYNTHESIS OF DRUG NANOPARTICLES BY SPRAY DRYING | THE PENN STATE RESEARCH FOUNDATION (US) | 1998-09-09 | — | — | EP | claimed |
| WO-1997013503-A9 | SYNTHESIS OF DRUG NANOPARTICLES BY SPRAY DRYING | — | 1997-07-31 | — | — | WO | claimed |
| WO-1997013503-A1 | SYNTHESIS OF DRUG NANOPARTICLES BY SPRAY DRYING | THE PENN STATE RESEARCH FOUNDATION (US) | 1997-04-17 | — | — | WO | claimed |
| US-4308627-A | Process for prevention of chalkbrood disease | WALLACE MELVIN W | 1982-01-05 | — | — | US | claimed |
| US-4070356-A | Manufacture of soluble sulfathiazole | MBH CHEMICAL CORPORATION (US) | 1978-01-24 | — | — | US | claimed |