Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.51 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.46 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.39 |
| ▸ | ATM | Q13315 | 7/20 | 0.38 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.38 |
| ▸ | HTR3B | O95264 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | HTR3A | P46098 | 1/20 | 0.38 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.38 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | RXRA | P19793 | 2/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2194786 | 0.82 | PDE10A (0.70) | PDE10AHCAR1ATMHTR3EHTR3B | |
| SCHEMBL2195321 | 0.79 | PDE10A (0.60) | PDE10AHCAR1ATMHTR3EHTR3B | |
| SCHEMBL2191698 | 0.79 | PDE10A (0.60) | PDE10AHCAR1ATMHTR3EHTR3B | |
| SCHEMBL2191972 | 0.75 | HCAR1 (0.55) | HCAR1CSF1RATMRXRAGRIN1 | |
| SCHEMBL2194911 | 0.72 | PDE10A (0.51) | PDE10AHCAR1ATMHTR3EHTR3B | |
| SCHEMBL31068655 | 0.71 | PDE10A (0.48) | PDE10AHTR3EHTR3BHTR1AHTR3A | |
| SCHEMBL2195431 | 0.69 | CDK1 (0.47) | PDE10AHCAR1HRH3HTR3EHTR3B | |
| SCHEMBL2192506 | 0.68 | EGFR (0.43) | HRH3MAOAMAOB | |
| SCHEMBL9300761 | 0.68 | GRM5 (0.46) | MAOAMAOB | |
| SCHEMBL2197007 | 0.67 | HCAR1 (0.47) | PDE10AHCAR1HTR3EHTR3BHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8507473-B2 | 3H-imidazo[4,5-b]pyridin-5-ol derivatives useful in the treatment of GPR81 receptor disorders | ARENA PHARMACEUTICALS, INC. (US) | 2013-08-13 | — | — | US | disclosed |
| US-20110172209-A1 | 3H-IMIDAZO[4,5-B]PYRIDIN-5-OL DERIVATIVES USEFUL IN THE TREATMENT OF GPR81 RECEPTOR DISORDERS | ARENA PHARMACEUTICALS, INC. (US) | 2011-07-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110172209-A1 | 3H-IMIDAZO[4,5-B]PYRIDIN-5-OL DERIVATIVES USEFUL IN THE TREATMENT OF GPR81 RECEPTOR DISORDERS | GPR84, GPR119, GPR65 | PDE10A 2688/4885HCAR1 28/4885CSF1R 338/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.