Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 5/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | USP2 | O75604 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.38 |
| ▸ | RAD52 | P43351 | 1/20 | 0.38 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17870867 | 0.80 | TSHR (0.41) | GAAKDM4EALDH1A1L3MBTL1MEN1 | |
| SCHEMBL17882362 | 0.80 | DPP4 (0.47) | GAAKDM4EALDH1A1L3MBTL1MEN1 | |
| SCHEMBL885606 | 0.77 | SCN2A (0.57) | GAAKDM4EALDH1A1L3MBTL1MEN1 | |
| SCHEMBL29395615 | 0.77 | SCN2A (0.57) | GAAKDM4EALDH1A1L3MBTL1MEN1 | |
| SCHEMBL17171655 | 0.74 | ADRA2C (0.47) | GAAKDM4EALDH1A1L3MBTL1MEN1 | |
| SCHEMBL14557127 | 0.73 | POLB (0.50) | GAAALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL23586295 | 0.73 | ADRA2C (0.47) | GAAKDM4EALDH1A1L3MBTL1MEN1 | |
| SCHEMBL21765588 | 0.73 | GAA (0.45) | GAAKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL31316643 | 0.73 | MAOA (0.50) | GAAKDM4EALDH1A1L3MBTL1MEN1 | |
| SCHEMBL31316644 | 0.73 | MAOA (0.50) | GAAKDM4EALDH1A1L3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10636979-B2 | Heterocyclic compounds with dibenzazapine structures | MERCK PATENT GMBH (DE) | 2020-04-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10636979-B2 | Heterocyclic compounds with dibenzazapine structures | DDT, MAOA, MAOB | GAA 1138/4885KDM4E 1175/4885ALDH1A1 371/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.