Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | TDP2 | O95551 | 1/20 | 0.31 |
| ▸ | CDC25A | P30304 | 1/20 | 0.30 |
| ▸ | CDC25B | P30305 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2196756 | 0.90 | JAK2 (0.38) | DGAT1TDP2 | |
| SCHEMBL2179546 | 0.88 | NPC1 (0.42) | KMT2A | |
| SCHEMBL2202235 | 0.88 | JAK2 (0.38) | DGAT1TDP2 | |
| SCHEMBL2197181 | 0.87 | HDAC4 (0.33) | — | |
| SCHEMBL2198728 | 0.85 | JAK2 (0.39) | DGAT1TDP2 | |
| SCHEMBL2199101 | 0.83 | ALDH1A1 (0.37) | — | |
| SCHEMBL2195168 | 0.80 | DGAT1 (0.36) | APPDGAT1PARP1 | |
| SCHEMBL2194260 | 0.80 | DGAT1 (0.39) | APPDGAT1 | |
| SCHEMBL2178868 | 0.78 | SLC2A1 (0.42) | — | |
| SCHEMBL2184971 | 0.77 | MEN1 (0.41) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519500-A1 | INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE | Piramal Healthcare Ltd. (IN) | 2012-11-07 | — | — | EP | disclosed |
| WO-2011080718-A1 | INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE | PIRAMAL LIFE SCIENCES LIMITED (IN) | 2011-07-07 | — | — | WO | disclosed |