Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | PRKACA | P17612 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.39 |
| ▸ | MST1R | Q04912 | 1/20 | 0.39 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.39 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.39 |
| ▸ | CAMK1D | Q8IU85 | 1/20 | 0.39 |
| ▸ | TDP2 | O95551 | 5/20 | 0.38 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.34 |
| ▸ | DGAT1 | O75907 | 3/20 | 0.33 |
| ▸ | HTR2A | P28223 | 2/20 | 0.32 |
| ▸ | HTR2C | P28335 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2196756 | 0.96 | JAK2 (0.38) | JAK2NTRK1METFGFR1PRKACA | |
| SCHEMBL2202235 | 0.96 | JAK2 (0.38) | JAK2NTRK1METFGFR1PRKACA | |
| SCHEMBL2178670 | 0.87 | SLC2A1 (0.43) | — | |
| SCHEMBL2194266 | 0.85 | APP (0.36) | TDP2DGAT1 | |
| SCHEMBL2178868 | 0.83 | SLC2A1 (0.42) | — | |
| SCHEMBL2179901 | 0.83 | SLC2A1 (0.42) | — | |
| SCHEMBL2197181 | 0.83 | HDAC4 (0.33) | — | |
| SCHEMBL2198725 | 0.79 | JAK2 (0.40) | JAK2NTRK1METFGFR1PRKACA | |
| SCHEMBL2199101 | 0.79 | ALDH1A1 (0.37) | HTR2AHTR2CCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL2199151 | 0.79 | MAPK1 (0.38) | JAK2NTRK1METFGFR1PRKACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519500-A1 | INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE | Piramal Healthcare Ltd. (IN) | 2012-11-07 | — | — | EP | disclosed |
| WO-2011080718-A1 | INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE | PIRAMAL LIFE SCIENCES LIMITED (IN) | 2011-07-07 | — | — | WO | disclosed |