Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5A | P29375 | 1/20 | 0.61 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.61 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.61 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.54 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.54 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 7/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 7/20 | 0.51 |
| ▸ | CLK4 | Q9HAZ1 | 7/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | USP2 | O75604 | 2/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27304412 | 0.82 | NTRK1 (0.61) | KDM5AKDM4CKDM5BNTRK1NTRK3 | |
| SCHEMBL34462781 | 0.80 | CLK4 (0.56) | CYP1A2CYP2C19CLK4CYP3A4CYP2D6 | |
| SCHEMBL1192209 | 0.78 | NTRK1 (0.49) | KDM5AKDM4CKDM5BNTRK1NTRK3 | |
| SCHEMBL29580072 | 0.78 | FABP1 (0.67) | KDM5AKDM4CKDM5BNTRK1NTRK3 | |
| SCHEMBL6301756 | 0.77 | FABP1 (0.61) | NTRK1NTRK3NTRK2CYP1A2CYP2C19 | |
| SCHEMBL993605 | 0.77 | EGLN2 (0.58) | NTRK1NTRK3NTRK2CYP3A4LMNA | |
| SCHEMBL3957462 | 0.75 | ALDH1A1 (0.68) | KDM5AKDM4CKDM5BNTRK1NTRK3 | |
| SCHEMBL4935560 | 0.75 | GRM5 (0.49) | CYP1A2GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL28257164 | 0.72 | APP (0.51) | KDM5AKDM4CKDM5BNTRK1NTRK3 | |
| SCHEMBL4778987 | 0.72 | KDM5A (0.51) | KDM5AKDM4CKDM5BNTRK1NTRK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110172230-A1 | UREA COMPOUND OR SALT THEREOF | ASTELLAS PHARMA INC. (JP) | 2011-07-14 | — | — | US | disclosed |
| EP-2065369-A1 | UREA COMPOUND OR SALT THEREOF | Astellas Pharma Inc. (JP) | 2009-06-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110172230-A1 | UREA COMPOUND OR SALT THEREOF | FAAH, FAAH2, UTS2R | KDM5A 301/4885KDM4C 448/4885KDM5B 304/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.