Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | LMNA | P02545 | 5/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.37 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21948021 | 0.80 | ZAP70 (0.39) | ALDH1A1LMNASMN1; SMN2NPC1RAB9A | |
| SCHEMBL21948020 | 0.75 | ALDH1A1 (0.40) | ALDH1A1LMNASMN1; SMN2NPC1RAB9A | |
| SCHEMBL2672825 | 0.71 | ATP4A (0.45) | ALDH1A1SMN1; SMN2RAB9AHTTMAPK1 | |
| SCHEMBL23993917 | 0.68 | ALDH1A1 (0.47) | ALDH1A1LMNASMN1; SMN2NPC1RAB9A | |
| SCHEMBL15688365 | 0.68 | ATP4A (0.38) | ALDH1A1SMN1; SMN2HTTKDM4ETSHR | |
| SCHEMBL12575121 | 0.67 | GABRA1 (0.47) | ALDH1A1LMNASMN1; SMN2NPC1RAB9A | |
| SCHEMBL2674372 | 0.67 | L3MBTL1 (0.42) | LMNA | |
| SCHEMBL12889093 | 0.66 | ALDH1A1 (0.54) | ALDH1A1LMNASMN1; SMN2KDM4ETSHR | |
| SCHEMBL12476483 | 0.66 | GABRA1 (0.43) | ALDH1A1LMNASMN1; SMN2NPC1RAB9A | |
| SCHEMBL9772645 | 0.65 | KDM4E (0.44) | SMN1; SMN2NPC1RAB9AHTTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020081508-A1 | TYK2 INHIBITORS AND USES THEREOF | NIMBUS LAKSHMI, INC. (US) | 2020-04-23 | — | — | WO | disclosed |