SCHEMBL219544

SCHEMBL219544

O=C(Cl)c1cnc2ccccc2n1

nearest known ligand 0.69

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.69
HPGD P15428 1/20 0.69
ALOX15 P16050 1/20 0.69
HSD17B10 Q99714 1/20 0.69
SMN1; SMN2 Q16637 1/20 0.62
PTK2 Q05397 1/20 0.56
RAB9A P51151 4/20 0.55
NPC1 O15118 3/20 0.55
MAPT P10636 2/20 0.53
KDM4E B2RXH2 1/20 0.53
GAA P10253 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3829125 0.93 ALDH1A1 (0.83) ALDH1A1HPGDALOX15HSD17B10SMN1; SMN2
SCHEMBL27347353 0.83 ALDH1A1 (0.74) ALDH1A1HPGDALOX15HSD17B10SMN1; SMN2
SCHEMBL29623278 0.82 ALDH1A1 (1.00) ALDH1A1HPGDALOX15HSD17B10SMN1; SMN2
SCHEMBL354679 0.82 ALDH1A1 (1.00) ALDH1A1HPGDALOX15HSD17B10SMN1; SMN2
SCHEMBL5358823 0.82 ALDH1A1 (0.71) ALDH1A1HPGDALOX15HSD17B10SMN1; SMN2
SCHEMBL7722058 0.81 ALDH1A1 (0.48) ALDH1A1HPGDALOX15HSD17B10SMN1; SMN2
Hydrochloric Acid SCHEMBL7808078 0.80 ALDH1A1 (0.96) ALDH1A1HPGDALOX15HSD17B10SMN1; SMN2
SCHEMBL29540343 0.80 ALDH1A1 (0.69) ALDH1A1HPGDALOX15HSD17B10SMN1; SMN2
Water SCHEMBL29724498 0.80 ALDH1A1 (0.96) ALDH1A1HPGDALOX15HSD17B10SMN1; SMN2
SCHEMBL851358 0.80 ALDH1A1 (0.69) ALDH1A1HPGDALOX15HSD17B10SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 468 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-2264786-A None JP disclosed
EP-4713018-A1 TRANSFECTION COMPOSITIONS SUITABLE FOR PRODUCING A BIOLOGICAL PRODUCT PolyPlus Transfection (FR) 2026-03-25 EP disclosed
EP-3710428-B1 MODULATORS OF THE INTEGRATED STRESS PATHWAY CALICO LIFE SCIENCES LLC (US) 2026-03-25 EP disclosed
US-20250170117-A1 MODULATORS OF ACKR3 AND USES THEREOF INTERAX BIOTECH AG (CH) 2025-05-29 US disclosed
EP-4486739-A1 MODULATORS OF ACKR3 AND USES THEREOF InterAx Biotech AG (CH) 2025-01-08 EP disclosed
WO-2024236194-A1 TRANSFECTION COMPOSITIONS SUITABLE FOR PRODUCING A BIOLOGICAL PRODUCT POLYPLUS TRANSFECTION (FR) 2024-11-21 WO disclosed
US-20240307382-A1 MODULATORS OF THE INTEGRATED STRESS PATHWAY ABBVIE INC. 2024-09-19 US disclosed
CN-112204009-B Modulators of integrated stress pathways 卡里科生命科学有限责任公司 2024-05-07 CN disclosed
WO-2023166190-A1 MODULATORS OF ACKR3 AND USES THEREOF INTERAX BIOTECH AG (CH) 2023-09-07 WO disclosed
EP-4238970-A1 MODULATORS OF ACKR3 AND USES THEREOF InterAx Biotech AG (CH) 2023-09-06 EP disclosed
EP-0013107-A1 16-Hydroxy-16-vinyl (or cyclopropyl)-prostan-1-ols and pharmaceutical compositions containing the same AMERICAN CYANAMID COMPANY (US) 1980-07-09 EP disclosed
US-4206151-A BRONCHODILATOR, ANTISECRETORY, HYPOTENSIVE AMERICAN CYANAMID COMPANY (US) 1980-06-03 US disclosed
US-4192677-A ELECTROGRAPHIC CHARGE TRANSFER COMPOUNDS RICOH CO., LTD. (JP) 1980-03-11 US disclosed
EP-0002590-A1 Novel prostaglandin compounds, processes for the preparation thereof and pharmaceutical compositions containing them AMERICAN CYANAMID COMPANY (US) 1979-06-27 EP disclosed
EP-0001989-A1 Substituted mercapto acid amides, process for their preparation, pharmaceutical composition containing same and their use MERCK & CO. INC. (US) 1979-05-30 EP disclosed
US-4141729-A 1,3,4-Oxadiazole derivatives and electrophotographic plates containing same RICOH COMPANY, LTD. (JP) 1979-02-27 US disclosed
US-4139533-A ANTIARRHYTHMIA AGENTS BRISTOL-MYERS COMPANY (US) 1979-02-13 US disclosed
US-4123440-A ANTIARRHYTHMIA AND ANTIFIBRILLATORY AGENTS BRISTOL-MYERS COMPANY (US) 1978-10-31 US disclosed
US-4122273-A PROPHYLACTIC, ANTIARRHYTHMIC BRISTOL-MYERS COMPANY (US) 1978-10-24 US disclosed
US-4088652-A Acylazabicyclohexanes AMERICAN CYANAMID COMPANY (US) 1978-05-09 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250170117-A1 MODULATORS OF ACKR3 AND USES THEREOF ACKR3, PROKR2, PROKR1 ALDH1A1 3187/4885HPGD 1401/4885ALOX15 3504/4885
US-20240307382-A1 MODULATORS OF THE INTEGRATED STRESS PATHWAY ATF4, ATF1, DDIT3 ALDH1A1 3433/4885HPGD 849/4885ALOX15 639/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.