Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 1/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26047491 | 0.92 | PDE3B (0.42) | PDE3BPDE3ABACE1KDM4EGAA | |
| SCHEMBL28413351 | 0.86 | POLB (0.44) | KDM4EALDH1A1HSD17B10USP2CYP3A4 | |
| SCHEMBL21957647 | 0.76 | NFKB1 (0.47) | PDE3BPDE3ABACE1KDM4EGAA | |
| SCHEMBL28614794 | 0.75 | TNFRSF1A (0.36) | BACE1MAPTCYP3A4 | |
| SCHEMBL26951403 | 0.75 | PDE3B (0.45) | PDE3BPDE3AKDM4EGAALMNA | |
| SCHEMBL5882994 | 0.75 | PDE3B (0.45) | PDE3BPDE3ABACE1KDM4EGAA | |
| SCHEMBL5882542 | 0.74 | PDE3B (0.44) | PDE3BPDE3ABACE1ALDH1A1LMNA | |
| SCHEMBL23327124 | 0.73 | CYP3A4 (0.60) | KDM4ETP53KMT2AMAPTLMNA | |
| SCHEMBL30545309 | 0.73 | CYP3A4 (0.60) | KDM4ETP53KMT2AMAPTLMNA | |
| SCHEMBL28614793 | 0.72 | CYP3A4 (0.35) | KDM4ENPC1TP53RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111184866-B | Combination treatment of bacterial infections | 香港中文大学 | 2023-12-19 | — | — | CN | disclosed |
| US-11690810-B2 | Combination treatment of bacterial infection | THE CHINESE UNIVERSITY OF HONG KONG (CN) | 2023-07-04 | — | — | US | disclosed |
| CN-111184866-A | Combination therapy for bacterial infections | 香港中文大学 | 2020-05-22 | — | — | CN | disclosed |
| US-20200155641-A1 | COMBINATION TREATMENT OF BACTERIAL INFECTION | THE CHINESE UNIVERSITY OF HONG KONG (CN) | 2020-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200155641-A1 | COMBINATION TREATMENT OF BACTERIAL INFECTION | PGC, NRDC, PYCARD | PDE3B 1380/4885PDE3A 1296/4885BACE1 1487/4885 |
| US-11690810-B2 | Combination treatment of bacterial infection | PGC, NRDC, PYCARD | PDE3B 1380/4885PDE3A 1296/4885BACE1 1487/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.