Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 1/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21957646 | 0.92 | PDE3B (0.43) | PDE3BPDE3ATSHRBACE1CYP3A4 | |
| SCHEMBL28413351 | 0.79 | POLB (0.44) | CYP3A4HPGDKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL12586318 | 0.74 | CYP3A4 (0.58) | TSHRBACE1CYP3A4HPGDGAA | |
| SCHEMBL4102407 | 0.73 | KMT2A (0.49) | TSHRBACE1CYP3A4HPGDGAA | |
| SCHEMBL21957647 | 0.71 | NFKB1 (0.47) | PDE3BPDE3ATSHRBACE1CYP3A4 | |
| SCHEMBL6934496 | 0.71 | CYP3A4 (0.38) | BACE1CYP3A4HPGDGAAKDM4E | |
| SCHEMBL26951403 | 0.71 | PDE3B (0.45) | PDE3BPDE3ATSHRCYP3A4HPGD | |
| SCHEMBL5882994 | 0.70 | PDE3B (0.45) | PDE3BPDE3ABACE1GAAKDM4E | |
| SCHEMBL5990756 | 0.70 | HSP90AB1 (0.47) | PDE3BPDE3ATSHRCYP3A4HPGD | |
| SCHEMBL5882542 | 0.69 | PDE3B (0.44) | PDE3BPDE3ABACE1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11690810-B2 | Combination treatment of bacterial infection | THE CHINESE UNIVERSITY OF HONG KONG (CN) | 2023-07-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11690810-B2 | Combination treatment of bacterial infection | PGC, NRDC, PYCARD | PDE3B 1380/4885PDE3A 1296/4885TSHR 4521/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.