Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | TLR9 | Q9NR96 | 7/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 7/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 7/20 | 0.38 |
| ▸ | ABL1 | P00519 | 2/20 | 0.37 |
| ▸ | EGFR | P00533 | 2/20 | 0.37 |
| ▸ | SRC | P12931 | 2/20 | 0.37 |
| ▸ | ABL2 | P42684 | 2/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.37 |
| ▸ | CDK9 | P50750 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21960838 | 0.83 | ALDH1A1 (0.39) | ABL1EGFRSRCABL2LCK | |
| SCHEMBL21960972 | 0.82 | MAP3K14 (0.40) | MAP3K14DRD2TLR9TLR8TLR7 | |
| SCHEMBL21960820 | 0.79 | NPSR1 (0.49) | DRD2ALDH1A1TSHRNPSR1 | |
| SCHEMBL21964544 | 0.76 | POLB (0.42) | ABL1SRCLCKMEN1KMT2A | |
| SCHEMBL21960831 | 0.76 | MAP3K14 (0.38) | MAP3K14DRD2ABL1SRCMEN1 | |
| SCHEMBL21960342 | 0.75 | MAP3K14 (0.39) | MAP3K14DRD2TLR9TLR8TLR7 | |
| SCHEMBL21964545 | 0.74 | MAP3K12 (0.41) | MAP3K14MEN1KMT2A | |
| SCHEMBL21960869 | 0.71 | L3MBTL1 (0.42) | MAP3K14MEN1KMT2ACRHR1NPSR1 | |
| SCHEMBL21961343 | 0.70 | KCNH2 (0.40) | MAP3K14MEN1KMT2ATSHRNPSR1 | |
| SCHEMBL21960348 | 0.70 | MAP3K14 (0.39) | MAP3K14MEN1KMT2AALDH1A1CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11136311-B2 | Heteroaromatic derivatives as NIK inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2021-10-05 | — | — | US | disclosed |
| EP-3478675-B1 | HETEROAROMATIC DERIVATIVES AS NIK INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2020-04-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11136311-B2 | Heteroaromatic derivatives as NIK inhibitors | NFKBIA, IKBKG, IKBKE | MAP3K14 4/4885DRD2 4703/4885TLR9 1157/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.