Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K12 | Q12852 | 4/20 | 0.41 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 7/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
| ▸ | PIK3R5 | Q8WYR1 | 1/20 | 0.37 |
| ▸ | PIK3R3 | Q92569 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21960912 | 0.86 | MAP3K12 (0.45) | MAP3K12MAP3K14GSK3BPIK3CDPIK3R2 | |
| SCHEMBL21960831 | 0.84 | MAP3K14 (0.38) | MAP3K14L3MBTL1POLBHRH1MEN1 | |
| SCHEMBL21964544 | 0.82 | POLB (0.42) | L3MBTL1POLBMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL21960896 | 0.80 | PIK3CD (0.39) | MAP3K12MAP3K14GSK3BPIK3CDPIK3R2 | |
| SCHEMBL21960838 | 0.79 | ALDH1A1 (0.39) | GSK3BMEN1KMT2A | |
| SCHEMBL21960342 | 0.78 | MAP3K14 (0.39) | MAP3K12MAP3K14PIK3CAPIK3CBL3MBTL1 | |
| SCHEMBL11697399 | 0.77 | L3MBTL1 (0.47) | L3MBTL1POLBMEN1MAPK1KMT2A | |
| SCHEMBL21961322 | 0.74 | MAP3K14 (0.42) | MAP3K14MEN1KMT2A | |
| SCHEMBL21960869 | 0.74 | L3MBTL1 (0.42) | MAP3K14PIK3CAL3MBTL1POLBMEN1 | |
| SCHEMBL21961343 | 0.73 | KCNH2 (0.40) | MAP3K14PIK3CDPIK3R2PIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11136311-B2 | Heteroaromatic derivatives as NIK inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2021-10-05 | — | — | US | disclosed |
| EP-3478675-B1 | HETEROAROMATIC DERIVATIVES AS NIK INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2020-04-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11136311-B2 | Heteroaromatic derivatives as NIK inhibitors | NFKBIA, IKBKG, IKBKE | MAP3K12 7/4885MAP3K14 4/4885GSK3B 180/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.