Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.41 |
| ▸ | PDE7A | Q13946 | 8/20 | 0.40 |
| ▸ | BRD4 | O60885 | 4/20 | 0.36 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.35 |
| ▸ | RET | P07949 | 2/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | BRD2 | P25440 | 1/20 | 0.33 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.33 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.33 |
| ▸ | APLNR | P35414 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21960344 | 0.80 | PDE7A (0.43) | BAZ2BPDE7ABRD4RETKDR | |
| SCHEMBL21960888 | 0.76 | BAZ2B (0.39) | BAZ2BPDE7ABRD4MAP3K14HRH3 | |
| SCHEMBL20489182 | 0.71 | BRD4 (0.45) | BAZ2BPDE7ABRD4BRD2BRD3 | |
| SCHEMBL21960357 | 0.69 | PDE7A (0.44) | PDE7AMAP3K14RETKDR | |
| SCHEMBL21961452 | 0.64 | ALDH1A1 (0.38) | PDE7ABRD4 | |
| SCHEMBL26416280 | 0.64 | PKM (0.47) | PDE7ABRD4 | |
| SCHEMBL24208422 | 0.63 | HCAR3 (0.43) | PDE7A | |
| SCHEMBL853429 | 0.62 | PDE7A (0.77) | PDE7A | |
| SCHEMBL2323117 | 0.62 | HCAR3 (0.42) | — | |
| SCHEMBL21964588 | 0.62 | HCAR3 (0.40) | PDE7A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3478675-B1 | HETEROAROMATIC DERIVATIVES AS NIK INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2020-04-22 | — | — | EP | disclosed |