Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 1/20 | 0.38 |
| ▸ | XDH | P47989 | 1/20 | 0.37 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.37 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.34 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.34 |
| ▸ | MAP3K5 | Q99683 | 3/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.33 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | F9 | P00740 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2184969 | 0.91 | MEN1 (0.45) | KIF11DHODHHDAC6MEN1KMT2A | |
| SCHEMBL2194260 | 0.87 | DGAT1 (0.39) | KIF11XDHSLC22A12MAP3K5DGAT1 | |
| SCHEMBL2202230 | 0.87 | JAK2 (0.38) | CNR1DGAT1 | |
| SCHEMBL2198162 | 0.86 | TDP2 (0.42) | KIF11MEN1KMT2ADGAT1 | |
| SCHEMBL2196753 | 0.85 | JAK2 (0.38) | XDHSLC22A12CNR1DGAT1 | |
| SCHEMBL2198725 | 0.82 | JAK2 (0.40) | XDHSLC22A12CNR1DGAT1 | |
| SCHEMBL13719331 | 0.81 | MAPT (0.41) | DHODHHDAC6MEN1KMT2ATRPV1 | |
| SCHEMBL2197181 | 0.81 | HDAC4 (0.33) | KIF11XDHSLC22A12HDAC4HDAC1 | |
| SCHEMBL13719194 | 0.80 | CREBBP (0.45) | HDAC1TRPV1TP53 | |
| SCHEMBL2181794 | 0.79 | MEN1 (0.47) | MEN1KMT2ATRPV1DGAT1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519500-A1 | INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE | Piramal Healthcare Ltd. (IN) | 2012-11-07 | — | — | EP | disclosed |
| WO-2011080718-A1 | INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE | PIRAMAL LIFE SCIENCES LIMITED (IN) | 2011-07-07 | — | — | WO | disclosed |