Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP2 | O95551 | 1/20 | 0.42 |
| ▸ | DGAT1 | O75907 | 5/20 | 0.42 |
| ▸ | KIF11 | P52732 | 3/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.37 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.37 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.37 |
| ▸ | APP | P05067 | 1/20 | 0.37 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
| ▸ | APOB | P04114 | 1/20 | 0.36 |
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2180710 | 0.90 | MEN1 (0.48) | DGAT1MEN1KMT2ARXFP1 | |
| SCHEMBL2181794 | 0.86 | MEN1 (0.47) | DGAT1MEN1KMT2ARXFP1APOB | |
| SCHEMBL2198725 | 0.86 | JAK2 (0.40) | TDP2DGAT1KDRGPR142 | |
| SCHEMBL2197176 | 0.86 | KIF11 (0.38) | DGAT1KIF11MEN1KMT2A | |
| SCHEMBL2196753 | 0.82 | JAK2 (0.38) | TDP2DGAT1KDRGPR142 | |
| SCHEMBL2194260 | 0.82 | DGAT1 (0.39) | DGAT1KIF11APPBRD4CREBBP | |
| SCHEMBL2202230 | 0.82 | JAK2 (0.38) | TDP2DGAT1BRD4CREBBPKDR | |
| SCHEMBL2180866 | 0.81 | DGAT1 (0.55) | DGAT1KIF11MEN1KMT2AKDR | |
| SCHEMBL2280666 | 0.80 | DGAT1 (0.39) | TDP2DGAT1KIF11HRH3BRD4 | |
| SCHEMBL13719131 | 0.80 | MEN1 (0.46) | DGAT1MEN1KMT2ARXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519500-A1 | INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE | Piramal Healthcare Ltd. (IN) | 2012-11-07 | — | — | EP | disclosed |
| WO-2011080718-A1 | INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE | PIRAMAL LIFE SCIENCES LIMITED (IN) | 2011-07-07 | — | — | WO | disclosed |