Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 3/20 | 0.38 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 4/20 | 0.36 |
| ▸ | CA12 | O43570 | 3/20 | 0.36 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 4/20 | 0.33 |
| ▸ | CA2 | P00918 | 3/20 | 0.33 |
| ▸ | CA7 | P43166 | 2/20 | 0.32 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.32 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | FPR3 | P25089 | 1/20 | 0.31 |
| ▸ | FPR2 | P25090 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21918067 | 0.86 | CHRNB2 (0.36) | CTSKCHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL16517603 | 0.84 | CTSK (0.38) | CTSKCHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL17898136 | 0.83 | CA14 (0.37) | CTSKCA14CA12CA1CA2 | |
| SCHEMBL19902206 | 0.83 | GABRR1 (0.38) | CTSKCHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL13163799 | 0.81 | CA14 (0.38) | CTSKCA14CA12CA1CA2 | |
| SCHEMBL26272251 | 0.81 | CTSK (0.34) | CTSKCHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL16941095 | 0.81 | CTSK (0.39) | CTSKCHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL3711368 | 0.80 | CTSK (0.38) | CTSKCHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL24752001 | 0.79 | CTSK (0.39) | CTSKCHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL12287124 | 0.78 | CA14 (0.40) | CTSKCHRNB2CHRNA4CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10745381-B2 | Substituted isoquinolines and phthalazines as rock kinase inhibitors | CERVELLO THERAPEUTICS, LLC. (US) | 2020-08-18 | — | — | US | disclosed |
| US-20200140412-A1 | ROCK KINASE INHIBITORS | CERVELLO THERAPEUTICS, LLC. | 2020-05-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10745381-B2 | Substituted isoquinolines and phthalazines as rock kinase inhibitors | ROCK1, ROCK2, CIT | CTSK 2819/4885CHRNB2 2011/4885CHRNA4 2506/4885 |
| US-20200140412-A1 | ROCK KINASE INHIBITORS | ROCK1, ROCK2, RHOA | CTSK 1438/4885CHRNB2 1635/4885CHRNA4 2449/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.