Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.47 |
| ▸ | MMP3 | P08254 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.42 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.41 |
| ▸ | PLAU | P00749 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21976229 | 0.83 | GAA (0.46) | HDAC6HDAC8HDAC1HDAC2HDAC7 | |
| SCHEMBL21976480 | 0.81 | HDAC6 (0.50) | HDAC6HDAC8HDAC1HDAC2HDAC4 | |
| SCHEMBL21976478 | 0.80 | ALOX5 (0.42) | HDAC6HDAC8HDAC1HDAC2HDAC4 | |
| SCHEMBL21976208 | 0.80 | PBRM1 (0.44) | HDAC6HDAC8HDAC1ALOX5KDM4E | |
| SCHEMBL21976956 | 0.78 | USP2 (0.46) | HDAC6HDAC8HDAC1HDAC2HDAC4 | |
| SCHEMBL3205512 | 0.75 | MEN1 (0.53) | KDM4E | |
| SCHEMBL21976936 | 0.75 | HDAC6 (0.44) | HDAC6HDAC8HDAC1HDAC2HDAC4 | |
| SCHEMBL21976232 | 0.74 | SMPD1 (0.45) | HDAC6HDAC8HDAC1HDAC2KDM4E | |
| SCHEMBL21976470 | 0.73 | HDAC6 (0.55) | HDAC6HDAC8HDAC1HDAC4ALOX5 | |
| SCHEMBL21976203 | 0.73 | GAA (0.49) | HDAC6HDAC8HDAC1HDAC2HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3294715-B1 | BENZIMIDAZOLE DERIVATES USEFUL AS INHIBITORS OF MAMMALIAN HISTONE DEACETYLASE ACTIVITY | KANCERA AB (SE) | 2020-05-06 | — | — | EP | disclosed |