Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 10/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.49 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.49 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.49 |
| ▸ | ACHE | P22303 | 2/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.41 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | DNMT1 | P26358 | 2/20 | 0.39 |
| ▸ | DNMT3A | Q9Y6K1 | 2/20 | 0.39 |
| ▸ | DNMT3L | Q9UJW3 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21976469 | 0.81 | HDAC6 (0.47) | HDAC6HDAC8HDAC1HDAC7HDAC9 | |
| SCHEMBL21976229 | 0.76 | GAA (0.46) | HDAC6HDAC8HDAC1HDAC7HDAC3 | |
| SCHEMBL21976478 | 0.76 | ALOX5 (0.42) | HDAC6HDAC8HDAC1HDAC7HDAC9 | |
| SCHEMBL21976956 | 0.74 | USP2 (0.46) | HDAC6HDAC8HDAC1HDAC7HDAC9 | |
| SCHEMBL21976208 | 0.71 | PBRM1 (0.44) | HDAC6HDAC8HDAC1ALOX5 | |
| SCHEMBL21976232 | 0.70 | SMPD1 (0.45) | HDAC6HDAC8HDAC1HDAC2TP53 | |
| SCHEMBL21976248 | 0.70 | HDAC6 (0.45) | HDAC6HDAC8NPC1MAPTRAB9A | |
| SCHEMBL2489108 | 0.67 | NPC1 (0.44) | NPC1TP53MAPTRAB9APTK2B | |
| SCHEMBL21976470 | 0.67 | HDAC6 (0.55) | HDAC6HDAC8HDAC1HDAC4NPC1 | |
| SCHEMBL21976203 | 0.67 | GAA (0.49) | HDAC6HDAC8HDAC1HDAC3HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3294715-B1 | BENZIMIDAZOLE DERIVATES USEFUL AS INHIBITORS OF MAMMALIAN HISTONE DEACETYLASE ACTIVITY | KANCERA AB (SE) | 2020-05-06 | — | — | EP | disclosed |