Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMPD1 | P17405 | 8/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21976307 | 0.90 | HDAC1 (0.41) | SMPD1HDAC1HDAC8HDAC6ALDH1A1 | |
| SCHEMBL21976490 | 0.88 | SMN1; SMN2 (0.40) | SMPD1HDAC1HDAC8HDAC6GAA | |
| SCHEMBL21976248 | 0.88 | HDAC6 (0.45) | SMPD1HDAC8HDAC6ALDH1A1MAPT | |
| SCHEMBL21976492 | 0.79 | SMPD1 (0.53) | SMPD1HDAC6SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL21976229 | 0.77 | GAA (0.46) | HDAC1HDAC8HDAC6GAASMN1; SMN2 | |
| SCHEMBL21976208 | 0.74 | PBRM1 (0.44) | HDAC1HDAC8HDAC6KDM4E | |
| SCHEMBL21976469 | 0.74 | HDAC6 (0.47) | HDAC1HDAC8HDAC6HDAC2KDM4E | |
| SCHEMBL21975927 | 0.74 | KDM4E (0.41) | SMPD1HDAC1HDAC8HDAC6KDM4E | |
| SCHEMBL21976306 | 0.73 | HDAC6 (0.47) | SMPD1HDAC8HDAC6MAPT | |
| SCHEMBL21976478 | 0.72 | ALOX5 (0.42) | HDAC1HDAC8HDAC6GAAHDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3294715-B1 | BENZIMIDAZOLE DERIVATES USEFUL AS INHIBITORS OF MAMMALIAN HISTONE DEACETYLASE ACTIVITY | KANCERA AB (SE) | 2020-05-06 | — | — | EP | disclosed |