Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKLR | P30613 | 12/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21976172 | 0.83 | PKLR (0.68) | PKLRALDH1A1MAPTHTTSMN1; SMN2 | |
| SCHEMBL21976325 | 0.82 | PKLR (0.67) | PKLRALDH1A1MAPTHTTSMN1; SMN2 | |
| SCHEMBL16084081 | 0.81 | PKLR (1.00) | PKLRALDH1A1MAPTLMNAPKM | |
| SCHEMBL21976639 | 0.80 | PKLR (0.52) | PKLRALDH1A1HTTSMN1; SMN2LMNA | |
| SCHEMBL21976577 | 0.80 | PKLR (0.68) | PKLRALDH1A1SMN1; SMN2GAAUSP2 | |
| SCHEMBL21976121 | 0.79 | PKLR (0.46) | PKLRALDH1A1HPGD | |
| SCHEMBL21976475 | 0.79 | PKLR (0.67) | PKLRALDH1A1LMNA | |
| SCHEMBL21977205 | 0.78 | PKLR (0.63) | PKLR | |
| SCHEMBL21976149 | 0.78 | PKLR (0.51) | PKLR | |
| SCHEMBL21976246 | 0.77 | PKLR (0.65) | PKLRALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970189-B1 | THERAPEUTIC COMPOUNDS AND COMPOSITIONS | AGIOS PHARMACEUTICALS INC (US) | 2020-05-06 | — | — | EP | disclosed |