Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKLR | P30613 | 12/20 | 0.63 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.48 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21976172 | 0.85 | PKLR (0.68) | PKLREPHX2AVPR1A | |
| SCHEMBL16083860 | 0.83 | PKLR (0.82) | PKLR | |
| SCHEMBL21976639 | 0.82 | PKLR (0.52) | PKLRAVPR1A | |
| SCHEMBL21976577 | 0.82 | PKLR (0.68) | PKLRAVPR1A | |
| SCHEMBL21976119 | 0.80 | PKLR (0.68) | PKLRAVPR1A | |
| SCHEMBL21976475 | 0.79 | PKLR (0.67) | PKLR | |
| SCHEMBL21976325 | 0.79 | PKLR (0.67) | PKLREPHX2AVPR1A | |
| SCHEMBL16130135 | 0.78 | PKLR (0.64) | PKLRAVPR1A | |
| SCHEMBL21976584 | 0.78 | PKLR (0.68) | PKLR | |
| SCHEMBL16084069 | 0.77 | PKLR (1.00) | PKLR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970189-B1 | THERAPEUTIC COMPOUNDS AND COMPOSITIONS | AGIOS PHARMACEUTICALS INC (US) | 2020-05-06 | — | — | EP | disclosed |