Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.35 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.35 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
| ▸ | PRKACA | P17612 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2196065 | 0.92 | ALPL (0.38) | BRD4CREBBPCYP2C9ADRA1AHRH1 | |
| SCHEMBL2180155 | 0.91 | HRH3 (0.40) | BRD4CXCR6 | |
| SCHEMBL2197874 | 0.90 | BRD4 (0.38) | BRD4CREBBPCYP2C9ADRA1AHRH1 | |
| SCHEMBL2198200 | 0.89 | MCHR1 (0.36) | BRD4CREBBPDPP4DPP8DPP9 | |
| SCHEMBL2202780 | 0.86 | CRBN (0.37) | DPP4DPP8DPP9DPP7CYP2C9 | |
| SCHEMBL2181271 | 0.85 | ABCB1 (0.43) | RAB9ACXCR6KMT2A | |
| SCHEMBL2195082 | 0.83 | MAPT (0.43) | MAPTKMT2A | |
| SCHEMBL13719516 | 0.82 | PTPN1 (0.41) | CREBBPKDM1ACRBNMAPTKMT2A | |
| SCHEMBL2197233 | 0.82 | DGAT1 (0.42) | BRD4CREBBPCYP2C9ADRA1AHRH1 | |
| SCHEMBL2197877 | 0.81 | JAK2 (0.34) | CYP2C9ADRA1AHRH1JAK2NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519500-A1 | INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE | Piramal Healthcare Ltd. (IN) | 2012-11-07 | — | — | EP | disclosed |
| WO-2011080718-A1 | INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE | PIRAMAL LIFE SCIENCES LIMITED (IN) | 2011-07-07 | — | — | WO | disclosed |