Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
| ▸ | SCN1A | P35498 | 3/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | APOB | P04114 | 3/20 | 0.34 |
| ▸ | MTTP | P55157 | 3/20 | 0.34 |
| ▸ | FPR2 | P25090 | 2/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.33 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.33 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2180267 | 0.92 | MEN1 (0.42) | MCHR1DPP4 | |
| SCHEMBL2197280 | 0.90 | DGAT1 (0.41) | MCHR1BRD4CREBBPSCN1ASCN5A | |
| SCHEMBL2279505 | 0.89 | SCN1A (0.39) | MCHR1BRD4CREBBPSCN1ASCN5A | |
| SCHEMBL2197775 | 0.89 | BRD4 (0.35) | BRD4CREBBPDPP4DPP8DPP9 | |
| SCHEMBL2196065 | 0.85 | ALPL (0.38) | BRD4CREBBP | |
| SCHEMBL2202780 | 0.84 | CRBN (0.37) | DPP4DPP8DPP9DPP7 | |
| SCHEMBL13718607 | 0.82 | DGAT1 (0.46) | MCHR1DPP4 | |
| SCHEMBL13719516 | 0.82 | PTPN1 (0.41) | MCHR1CREBBP | |
| SCHEMBL2180155 | 0.81 | HRH3 (0.40) | MCHR1BRD4 | |
| SCHEMBL2196468 | 0.81 | MCHR1 (0.39) | MCHR1BRD4CREBBPSCN1ASCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519500-A1 | INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE | Piramal Healthcare Ltd. (IN) | 2012-11-07 | — | — | EP | disclosed |
| WO-2011080718-A1 | INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE | PIRAMAL LIFE SCIENCES LIMITED (IN) | 2011-07-07 | — | — | WO | disclosed |