Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 2/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.40 |
| ▸ | ALPL | P05186 | 1/20 | 0.39 |
| ▸ | ALPI | P09923 | 1/20 | 0.39 |
| ▸ | ALPG | P10696 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MGLL | Q99685 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 2/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2197874 | 0.92 | BRD4 (0.38) | DGAT1BRD4CREBBPHRH1CYP2C9 | |
| SCHEMBL2196065 | 0.91 | ALPL (0.38) | DGAT1BRD4CREBBPALPLALPI | |
| SCHEMBL2201496 | 0.89 | MGLL (0.40) | DGAT1BRD4CREBBPALPLALPI | |
| SCHEMBL2179475 | 0.87 | ACHE (0.43) | DGAT1KMT2AGRM5 | |
| SCHEMBL2197280 | 0.84 | DGAT1 (0.41) | DGAT1BRD4CREBBPKMT2A | |
| SCHEMBL2197237 | 0.83 | MAPK1 (0.34) | DGAT1ALPLALPIALPGKMT2A | |
| SCHEMBL2181331 | 0.82 | SLC2A1 (0.41) | DGAT1 | |
| SCHEMBL2197775 | 0.82 | BRD4 (0.35) | BRD4CREBBPKMT2AHRH1CYP2C9 | |
| SCHEMBL13719434 | 0.80 | KDM1A (0.44) | DGAT1CREBBP | |
| SCHEMBL2197846 | 0.80 | JAK2 (0.38) | BRD4CREBBPHRH1CYP2C9ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519500-A1 | INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE | Piramal Healthcare Ltd. (IN) | 2012-11-07 | — | — | EP | disclosed |
| WO-2011080718-A1 | INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE | PIRAMAL LIFE SCIENCES LIMITED (IN) | 2011-07-07 | — | — | WO | disclosed |