Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AOC3 | Q16853 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | GABBR2 | O75899 | 3/20 | 0.40 |
| ▸ | GABBR1 | Q9UBS5 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20660981 | 1.00 | AOC3 (0.41) | AOC3BRD4GABBR2GABBR1LMNA | |
| SCHEMBL21979530 | 1.00 | AOC3 (0.41) | AOC3BRD4GABBR2GABBR1LMNA | |
| SCHEMBL16333187 | 0.84 | GAA (0.46) | CYP3A4CYP2D6ALDH1A1CYP2C19TSHR | |
| SCHEMBL18222240 | 0.79 | SLC6A4 (0.38) | BRD4GABBR2GABBR1LMNACYP2C9 | |
| SCHEMBL29944688 | 0.77 | ABCB1 (0.46) | LMNACYP2C9CYP3A4ALDH1A1RAB9A | |
| SCHEMBL29944719 | 0.77 | ABCB1 (0.46) | LMNACYP2C9CYP3A4ALDH1A1RAB9A | |
| SCHEMBL21798511 | 0.77 | MTOR (0.45) | AOC3BRD4GABBR2GABBR1LMNA | |
| SCHEMBL21798508 | 0.77 | MTOR (0.45) | AOC3BRD4GABBR2GABBR1LMNA | |
| SCHEMBL21979525 | 0.74 | LMNA (0.35) | AOC3LMNACYP3A4CYP2D6BLM | |
| SCHEMBL21979527 | 0.74 | LMNA (0.35) | AOC3LMNACYP3A4CYP2D6BLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11479533-B2 | Inhibitors of Rho associated coiled-coil containing protein kinase | KADMON CORPORATION, LLC (US) | 2022-10-25 | — | — | US | disclosed |
| US-20200165206-A1 | INHIBITORS OF RHO ASSOCIATED COILED-COIL CONTAINING PROTEIN KINASE | KADMON CORPORATION, LLC | 2020-05-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11479533-B2 | Inhibitors of Rho associated coiled-coil containing protein kinase | ROCK1, ROCK2, RHOT2 | AOC3 3700/4885BRD4 1410/4885GABBR2 4000/4885 |
| US-20200165206-A1 | INHIBITORS OF RHO ASSOCIATED COILED-COIL CONTAINING PROTEIN KINASE | ROCK1, ROCK2, RHOT2 | AOC3 3700/4885BRD4 1410/4885GABBR2 4000/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.