Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | UTS2R | Q9UKP6 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29944688 | 1.00 | ABCB1 (0.46) | ABCB1TP53POLBRXFP1ALDH1A1 | |
| SCHEMBL20661098 | 0.83 | ALDH1A1 (0.46) | ABCB1TP53POLBRXFP1ALDH1A1 | |
| SCHEMBL20661074 | 0.83 | ALDH1A1 (0.46) | ABCB1TP53POLBRXFP1ALDH1A1 | |
| SCHEMBL20661073 | 0.83 | ALDH1A1 (0.46) | ABCB1TP53POLBRXFP1ALDH1A1 | |
| SCHEMBL29944667 | 0.81 | ABCB1 (0.39) | ABCB1TP53POLBRXFP1UTS2R | |
| SCHEMBL29944709 | 0.81 | ABCB1 (0.39) | ABCB1TP53POLBRXFP1UTS2R | |
| SCHEMBL7392945 | 0.79 | ABCB1 (0.52) | ABCB1ALDH1A1MEN1KMT2AOPRK1 | |
| SCHEMBL21979530 | 0.77 | AOC3 (0.41) | POLBALDH1A1UTS2RMEN1LMNA | |
| SCHEMBL20660981 | 0.77 | AOC3 (0.41) | POLBALDH1A1UTS2RMEN1LMNA | |
| SCHEMBL21979520 | 0.77 | AOC3 (0.41) | POLBALDH1A1UTS2RMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11479533-B2 | Inhibitors of Rho associated coiled-coil containing protein kinase | KADMON CORPORATION, LLC (US) | 2022-10-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11479533-B2 | Inhibitors of Rho associated coiled-coil containing protein kinase | ROCK1, ROCK2, RHOT2 | ABCB1 4058/4885TP53 2687/4885POLB 4116/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.