Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 6/20 | 0.39 |
| ▸ | TDP2 | O95551 | 1/20 | 0.36 |
| ▸ | FPR2 | P25090 | 3/20 | 0.35 |
| ▸ | FPR1 | P21462 | 2/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 2/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.34 |
| ▸ | APOB | P04114 | 2/20 | 0.34 |
| ▸ | BRD2 | P25440 | 1/20 | 0.34 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.34 |
| ▸ | MTTP | P55157 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.33 |
| ▸ | KIF11 | P52732 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2198162 | 0.80 | TDP2 (0.42) | DGAT1TDP2HRH3BRD4CREBBP | |
| SCHEMBL2280669 | 0.79 | DGAT1 (0.37) | DGAT1TDP2FPR2FPR1OPRD1 | |
| SCHEMBL2279512 | 0.77 | MCHR1 (0.39) | DGAT1TDP2OPRD1BRD4CREBBP | |
| SCHEMBL2197280 | 0.75 | DGAT1 (0.41) | DGAT1FPR2FPR1BRD4CREBBP | |
| SCHEMBL2196467 | 0.74 | MCHR1 (0.39) | DGAT1TDP2FPR2FPR1BRD4 | |
| SCHEMBL2196468 | 0.74 | MCHR1 (0.39) | DGAT1TDP2FPR2FPR1BRD4 | |
| SCHEMBL2197176 | 0.73 | KIF11 (0.38) | DGAT1KIF11 | |
| SCHEMBL2181794 | 0.72 | MEN1 (0.47) | DGAT1APOBMCHR1P2RY14 | |
| SCHEMBL2296052 | 0.72 | SDCBP (0.43) | DGAT1BRD4CREBBP | |
| SCHEMBL2180710 | 0.72 | MEN1 (0.48) | DGAT1MCHR1P2RY14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2519500-A1 | INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE | Piramal Healthcare Ltd. (IN) | 2012-11-07 | — | — | EP | disclosed |
| WO-2011080718-A1 | INHIBITORS OF DIACYLGLYCEROL ACYL TRANSFERASE | PIRAMAL LIFE SCIENCES LIMITED (IN) | 2011-07-07 | — | — | WO | disclosed |