Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HNF4A | P41235 | 1/20 | 0.53 |
| ▸ | IGFBP5 | P24593 | 6/20 | 0.52 |
| ▸ | IGFBP3 | P17936 | 2/20 | 0.52 |
| ▸ | IDH1 | O75874 | 1/20 | 0.47 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.47 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.46 |
| ▸ | MPO | P05164 | 1/20 | 0.44 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.43 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.43 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.43 |
| ▸ | IP6K3 | Q96PC2 | 1/20 | 0.43 |
| ▸ | IP6K2 | Q9UHH9 | 1/20 | 0.43 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.42 |
| ▸ | CTSB | P07858 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.42 |
| ▸ | DNMT3B | Q9UBC3 | 1/20 | 0.42 |
| ▸ | DNMT3L | Q9UJW3 | 1/20 | 0.42 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2908197 | 0.82 | ALDH1A1 (0.49) | IGFBP5IGFBP3 | |
| SCHEMBL6080457 | 0.81 | HCAR2 (0.46) | HNF4AIGFBP5IGFBP3IDH1HCAR2 | |
| SCHEMBL2910287 | 0.78 | MCL1 (0.55) | IP6K1 | |
| Transtorine SCHEMBL22979 | 0.77 | ALOX15 (0.60) | IGFBP5IGFBP3ACMSD | |
| Transtorine SCHEMBL17596601 | 0.77 | ALOX15 (0.60) | IGFBP5IGFBP3ACMSD | |
| SCHEMBL6593358 | 0.77 | KDM5B (0.55) | HNF4AIDH1KDM5BMPOEGLN1 | |
| SCHEMBL2908447 | 0.76 | IGFBP5 (0.43) | IGFBP5IGFBP3 | |
| SCHEMBL975885 | 0.76 | IGFBP5 (0.43) | IGFBP5IGFBP3 | |
| Transtorine SCHEMBL1421892 | 0.76 | ALOX15 (0.58) | IGFBP5IGFBP3ACMSD | |
| Transtorine SCHEMBL480985 | 0.76 | ALOX15 (0.58) | IGFBP5IGFBP3ACMSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3659593-A1 | TRMT2A INHIBITORS FOR USE IN THE TREATMENT OF POLYGLUTAMINE DISEASES | Forschungszentrum Jülich GmbH/ Abteilung RP-PT (DE) | 2020-06-03 | — | — | EP | disclosed |