Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA9 | Q16790 | 1/20 | 0.52 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.48 |
| ▸ | MAP1LC3A | Q9H492 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.44 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | NPY4R | P50391 | 7/20 | 0.42 |
| ▸ | NPY1R | P25929 | 5/20 | 0.42 |
| ▸ | NPY5R | Q15761 | 4/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29419661 | 1.00 | CA12 (0.52) | CA12CA1CA9MAP1LC3BMAP1LC3A | |
| SCHEMBL17821546 | 1.00 | CA12 (0.52) | CA12CA1CA9MAP1LC3BMAP1LC3A | |
| Hydrochloric Acid SCHEMBL11217796 | 0.97 | CA1 (0.49) | CA12CA1CA9MAP1LC3BMAP1LC3A | |
| SCHEMBL14050068 | 0.94 | CA12 (0.49) | CA12CA1CA9MAP1LC3BMAP1LC3A | |
| SCHEMBL29405051 | 0.94 | CA12 (0.49) | CA12CA1CA9MAP1LC3BMAP1LC3A | |
| SCHEMBL2334528 | 0.93 | CA12 (0.45) | CA12CA1CA9MAP1LC3BMAP1LC3A | |
| Acetic Acid SCHEMBL644616 | 0.93 | CA1 (0.47) | CA12CA1CA9MAP1LC3BMAP1LC3A | |
| SCHEMBL6916459 | 0.92 | CA1 (0.51) | CA12CA1CA9MAP1LC3BMAP1LC3A | |
| SCHEMBL29543720 | 0.92 | CA1 (0.51) | CA12CA1CA9MAP1LC3BMAP1LC3A | |
| SCHEMBL29543863 | 0.92 | CA1 (0.53) | CA12CA1CA9KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160347792-A1 | FLUORINATED EPOXYKETONE-BASED COMPOUNDS AND USES THEREOF AS PROTEASOME INHIBITORS | TRILLIUM THERAPEUTICS INC. (CA) | 2016-12-01 | — | — | US | disclosed |
| US-9441012-B2 | Fluorinated epoxyketone-based compounds and uses thereof as proteasome inhibitors | TRILLIUM THERAPEUTICS INC. (CA) | 2016-09-13 | — | — | US | disclosed |
| US-20150218212-A1 | FLUORINATED EPOXYKETONE-BASED TETRAPEPTIDE COMPOUNDS AND USES THEREOF AS PROTEASOME INHIBITORS | FLUORINOV PHARMA INC. (CA) | 2015-08-06 | — | — | US | disclosed |
| US-20150203534-A1 | FLUORINATED EPOXYKETONE-BASED COMPOUNDS AND USES THEREOF AS PROTEASOME INHIBITORS | FLUORINOV PHARMA INC. (CA) | 2015-07-23 | — | — | US | disclosed |
| EP-2885314-A1 | FLUORINATED EPOXYKETONE-BASED COMPOUNDS AND USES THEREOF AS PROTEASOME INHIBITORS | Fluorinov Pharma Inc. (CA) | 2015-06-24 | — | — | EP | disclosed |
| WO-2014161072-A1 | Α-BORYL ISOCYANIDES, BOROPEPTIDES AND BORON HETEROCYCLES | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) | 2014-10-09 | — | — | WO | disclosed |
| CN-102137682-B | Anti-hepatitis c virus composition | UNIV OSAKA | 2014-07-02 | — | — | CN | disclosed |
| EP-2351585-B1 | ANTI-HEPATITIS C VIRUS COMPOSITION COMPRISING A NUCLEIC ACID THAT IS DIRECTED AGAINST PA28-GAMMA | UNIV OSAKA (JP) | 2014-03-26 | — | — | EP | disclosed |
| WO-2014029022-A1 | FLUORINATED EPOXYKETONE-BASED TETRAPEPTIDE COMPOUNDS AND USES THEREOF AS PROTEASOME INHIBITORS | SLASSI ABDELMALIK (CA) | 2014-02-27 | — | — | WO | disclosed |
| WO-2014026282-A1 | FLUORINATED EPOXYKETONE-BASED COMPOUNDS AND USES THEREOF AS PROTEASOME INHIBITORS | SLASSI ABDELMALIK (CA) | 2014-02-20 | — | — | WO | disclosed |
| US-8580759-B2 | Anti-hepatitis C virus composition | OSAKA UNIVERSITY (JP) | 2013-11-12 | — | — | US | disclosed |
| EP-2351585-A1 | ANTI-HEPATITIS C VIRUS COMPOSITION | Osaka University (JP) | 2011-08-03 | — | — | EP | disclosed |
| CN-102137682-A | Anti-hepatitis c virus composition | UNIV OSAKA | 2011-07-27 | — | — | CN | disclosed |
| US-20110166203-A1 | ANTI-HEPATITIS C VIRUS COMPOSITION | OSAKA UNIVERSITY (JP) | 2011-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160347792-A1 | FLUORINATED EPOXYKETONE-BASED COMPOUNDS AND USES THEREOF AS PROTEASOME INHIBITORS | PSMB5, PSMB1, PSMB7 | CA12 4522/4885CA1 4216/4885CA9 4400/4885 |
| US-20150218212-A1 | FLUORINATED EPOXYKETONE-BASED TETRAPEPTIDE COMPOUNDS AND USES THEREOF AS PROTEASOME INHIBITORS | PSMA1, PSMB1, PSMB11 | CA12 4381/4885CA1 3627/4885CA9 4353/4885 |
| US-20150203534-A1 | FLUORINATED EPOXYKETONE-BASED COMPOUNDS AND USES THEREOF AS PROTEASOME INHIBITORS | PSMB5, PSMB1, PSMB7 | CA12 4499/4885CA1 4220/4885CA9 4397/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.