Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S100A4 | P26447 | 1/20 | 0.36 |
| ▸ | HKDC1 | Q2TB90 | 2/20 | 0.33 |
| ▸ | PADI1 | Q9ULC6 | 1/20 | 0.33 |
| ▸ | PADI3 | Q9ULW8 | 1/20 | 0.33 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.33 |
| ▸ | PADI2 | Q9Y2J8 | 1/20 | 0.33 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | TDP2 | O95551 | 1/20 | 0.33 |
| ▸ | NSD2 | O96028 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21998582 | 0.80 | TTR (0.36) | MAPTRAB9ACA1CA2TDP2 | |
| SCHEMBL19308154 | 0.80 | TTR (0.36) | MAPTRAB9ACA1CA2TDP2 | |
| SCHEMBL21931643 | 0.80 | BLM (0.41) | S100A4HKDC1PADI1PADI3PADI4 | |
| SCHEMBL21998585 | 0.77 | CYP1B1 (0.41) | NPC1TP53MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL19308167 | 0.77 | CYP1B1 (0.41) | NPC1TP53MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL21998588 | 0.77 | ALDH1A1 (0.34) | CA1CA2TDP2NSD2ABL1 | |
| SCHEMBL21993899 | 0.70 | MAPT (0.51) | MAPTCA1CA2CES1MEN1 | |
| SCHEMBL13495402 | 0.69 | CYP2D6 (0.50) | S100A4HKDC1PADI1PADI3PADI4 | |
| SCHEMBL798345 | 0.61 | GAA (0.52) | TP53MAPTRAB9ASMN1; SMN2MEN1 | |
| SCHEMBL30219494 | 0.61 | GAA (0.52) | TP53MAPTRAB9ASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10722500-B2 | Gossypol 7-N-isatin Schiff base compounds with antitumor activities and a method of preparing the same | SHAANXI PANLONG PHARMACEUTICAL GROUP LIMITED BY SHARE LTD. (CN) | 2020-07-28 | — | — | US | disclosed |
| US-20200147057-A1 | GOSSYPOL 7-N-ISATIN SCHIFF BASE COMPOUNDS WITH ANTITUMOR ACTIVITIES AND A METHOD OF PREPARING THE SAME | SHAANXI PANLONG PHARMACEUTICAL GROUP LIMITED BY SHARE LTD. (CN) | 2020-05-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10722500-B2 | Gossypol 7-N-isatin Schiff base compounds with antitumor activities and a method of preparing the same | HASPIN, GGPS1, GNA15 | S100A4 1356/4885HKDC1 4167/4885PADI1 2600/4885 |
| US-20200147057-A1 | GOSSYPOL 7-N-ISATIN SCHIFF BASE COMPOUNDS WITH ANTITUMOR ACTIVITIES AND A METHOD OF PREPARING THE SAME | HASPIN, GGPS1, GNA15 | S100A4 1356/4885HKDC1 4167/4885PADI1 2600/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.