Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 4/20 | 0.36 |
| ▸ | CA2 | P00918 | 4/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | TDP2 | O95551 | 1/20 | 0.35 |
| ▸ | NSD2 | O96028 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.35 |
| ▸ | CES1 | P23141 | 1/20 | 0.35 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.35 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 5/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19308154 | 1.00 | TTR (0.36) | TTRCA1CA2CA12CA9 | |
| SCHEMBL21998588 | 0.80 | ALDH1A1 (0.34) | CA1CA2TNKS2TDP1TDP2 | |
| SCHEMBL21998585 | 0.80 | CYP1B1 (0.41) | CA1CA2CA12CA9MEN1 | |
| SCHEMBL21993882 | 0.80 | S100A4 (0.36) | CA1CA2TDP1TDP2NSD2 | |
| SCHEMBL19308167 | 0.80 | CYP1B1 (0.41) | CA1CA2CA12CA9MEN1 | |
| SCHEMBL20218196 | 0.78 | CES1 (0.41) | TTRTDP1TDP2NSD2ABL1 | |
| SCHEMBL2477071 | 0.78 | CASP3 (0.52) | TTRTDP1TDP2NSD2ABL1 | |
| SCHEMBL19308152 | 0.77 | TNKS2 (0.33) | TTRTNKS2TDP2NSD2ABL1 | |
| SCHEMBL19308146 | 0.77 | CYP1B1 (0.38) | KMT2ABRD4MAPT | |
| SCHEMBL21993899 | 0.74 | MAPT (0.51) | CA1CA2CA12CA9CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10722500-B2 | Gossypol 7-N-isatin Schiff base compounds with antitumor activities and a method of preparing the same | SHAANXI PANLONG PHARMACEUTICAL GROUP LIMITED BY SHARE LTD. (CN) | 2020-07-28 | — | — | US | disclosed |
| US-20200147057-A1 | GOSSYPOL 7-N-ISATIN SCHIFF BASE COMPOUNDS WITH ANTITUMOR ACTIVITIES AND A METHOD OF PREPARING THE SAME | SHAANXI PANLONG PHARMACEUTICAL GROUP LIMITED BY SHARE LTD. (CN) | 2020-05-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10722500-B2 | Gossypol 7-N-isatin Schiff base compounds with antitumor activities and a method of preparing the same | HASPIN, GGPS1, GNA15 | TTR 4315/4885CA1 2660/4885CA2 2639/4885 |
| US-20200147057-A1 | GOSSYPOL 7-N-ISATIN SCHIFF BASE COMPOUNDS WITH ANTITUMOR ACTIVITIES AND A METHOD OF PREPARING THE SAME | HASPIN, GGPS1, GNA15 | TTR 4315/4885CA1 2660/4885CA2 2639/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.