Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 3/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.38 |
| ▸ | CASP1 | P29466 | 3/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MPI | P34949 | 1/20 | 0.38 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.38 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19308167 | 1.00 | CYP1B1 (0.41) | CYP1B1CA2CA12CA9BRD4 | |
| SCHEMBL21993899 | 0.82 | MAPT (0.51) | CA2CA12CA9BRD4ALDH1A1 | |
| SCHEMBL19308146 | 0.82 | CYP1B1 (0.38) | CYP1B1BRD4ALDH1A1SMN1; SMN2CASP1 | |
| SCHEMBL19308154 | 0.80 | TTR (0.36) | CA2CA12CA9BRD4KMT2A | |
| SCHEMBL21998582 | 0.80 | TTR (0.36) | CA2CA12CA9BRD4KMT2A | |
| SCHEMBL19297675 | 0.80 | BRD4 (0.43) | CYP1B1BRD4ALDH1A1SMN1; SMN2CASP1 | |
| SCHEMBL19308145 | 0.79 | BRD4 (0.35) | CYP1B1CA2CA12CA9BRD4 | |
| SCHEMBL19308157 | 0.79 | BRD4 (0.52) | BRD4ALDH1A1HPGDKMT2AMAPT | |
| SCHEMBL21993882 | 0.77 | S100A4 (0.36) | CA2ALDH1A1SMN1; SMN2HPGDKMT2A | |
| SCHEMBL21998588 | 0.77 | ALDH1A1 (0.34) | CA2ALDH1A1KMT2AMEN1CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10722500-B2 | Gossypol 7-N-isatin Schiff base compounds with antitumor activities and a method of preparing the same | SHAANXI PANLONG PHARMACEUTICAL GROUP LIMITED BY SHARE LTD. (CN) | 2020-07-28 | — | — | US | disclosed |
| US-20200147057-A1 | GOSSYPOL 7-N-ISATIN SCHIFF BASE COMPOUNDS WITH ANTITUMOR ACTIVITIES AND A METHOD OF PREPARING THE SAME | SHAANXI PANLONG PHARMACEUTICAL GROUP LIMITED BY SHARE LTD. (CN) | 2020-05-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10722500-B2 | Gossypol 7-N-isatin Schiff base compounds with antitumor activities and a method of preparing the same | HASPIN, GGPS1, GNA15 | CYP1B1 1316/4885CA2 2639/4885CA12 1078/4885 |
| US-20200147057-A1 | GOSSYPOL 7-N-ISATIN SCHIFF BASE COMPOUNDS WITH ANTITUMOR ACTIVITIES AND A METHOD OF PREPARING THE SAME | HASPIN, GGPS1, GNA15 | CYP1B1 1316/4885CA2 2639/4885CA12 1078/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.