Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
| ▸ | APP | P05067 | 2/20 | 0.43 |
| ▸ | SNCA | P37840 | 2/20 | 0.43 |
| ▸ | TNKS2 | Q9H2K2 | 6/20 | 0.40 |
| ▸ | CTRC | Q99895 | 1/20 | 0.39 |
| ▸ | RAF1 | P04049 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | TDP2 | O95551 | 1/20 | 0.37 |
| ▸ | NSD2 | O96028 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29759335 | 0.76 | CYP1A2 (0.59) | CYP1A2SMN1; SMN2MAPTALDH1A1GAA | |
| SCHEMBL22806019 | 0.76 | CYP1A2 (0.59) | CYP1A2SMN1; SMN2MAPTALDH1A1GAA | |
| SCHEMBL2493976 | 0.76 | CYP1A2 (0.59) | CYP1A2SMN1; SMN2MAPTALDH1A1GAA | |
| SCHEMBL20218242 | 0.76 | CYP1A2 (0.59) | CYP1A2SMN1; SMN2MAPTALDH1A1GAA | |
| SCHEMBL6246169 | 0.73 | ALDH1A1 (0.43) | CYP1A2SMN1; SMN2MAPTALDH1A1GAA | |
| SCHEMBL6246167 | 0.73 | ALDH1A1 (0.43) | CYP1A2SMN1; SMN2MAPTALDH1A1GAA | |
| SCHEMBL7741266 | 0.72 | CYP1A2 (0.44) | CYP1A2SMN1; SMN2MAPTALDH1A1GAA | |
| SCHEMBL3544607 | 0.71 | LRRK2 (0.62) | MAPTALDH1A1GAAMEN1KMT2A | |
| SCHEMBL3613979 | 0.71 | LRRK2 (0.62) | MAPTALDH1A1GAAMEN1KMT2A | |
| SCHEMBL5740660 | 0.71 | LRRK2 (0.62) | MAPTALDH1A1GAAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10722500-B2 | Gossypol 7-N-isatin Schiff base compounds with antitumor activities and a method of preparing the same | SHAANXI PANLONG PHARMACEUTICAL GROUP LIMITED BY SHARE LTD. (CN) | 2020-07-28 | — | — | US | disclosed |
| US-20200147057-A1 | GOSSYPOL 7-N-ISATIN SCHIFF BASE COMPOUNDS WITH ANTITUMOR ACTIVITIES AND A METHOD OF PREPARING THE SAME | SHAANXI PANLONG PHARMACEUTICAL GROUP LIMITED BY SHARE LTD. (CN) | 2020-05-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10722500-B2 | Gossypol 7-N-isatin Schiff base compounds with antitumor activities and a method of preparing the same | HASPIN, GGPS1, GNA15 | CYP1A2 2969/4885SMN1; SMN2 2367/4885MAPT 4682/4885 |
| US-20200147057-A1 | GOSSYPOL 7-N-ISATIN SCHIFF BASE COMPOUNDS WITH ANTITUMOR ACTIVITIES AND A METHOD OF PREPARING THE SAME | HASPIN, GGPS1, GNA15 | CYP1A2 2969/4885SMN1; SMN2 2367/4885MAPT 4682/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.