Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.50 |
| ▸ | CYP2A6 | P11509 | 4/20 | 0.44 |
| ▸ | CYP2B6 | P20813 | 3/20 | 0.44 |
| ▸ | CYP2E1 | P05181 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.36 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.36 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 4/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Biphenyl SCHEMBL27870612 | 0.98 | NOTUM (0.48) | NOTUMCYP2A6CYP2B6CYP2E1ALDH1A1 | |
| Hydrochlorthiazide SCHEMBL4761882 | 0.89 | NOTUM (0.39) | NOTUMCYP2A6CYP2B6CYP2E1ALDH1A1 | |
| Benzene SCHEMBL7782550 | 0.84 | TSHR (0.33) | TSHR | |
| Hydrochlorthiazide SCHEMBL28136222 | 0.84 | NPC1 (0.47) | ALDH1A1CYP19A1NPC1RAB9AKDM4E | |
| Naphthalene SCHEMBL303703 | 0.83 | CYP2A6 (0.40) | CYP2A6ALDH1A1CYP19A1 | |
| Benzenethiol SCHEMBL11811993 | 0.82 | NOTUM (0.31) | NOTUM | |
| Fluorobenzene SCHEMBL10655817 | 0.82 | MAPK14 (0.32) | NOTUMKDM4E | |
| Iodobenzene SCHEMBL27608478 | 0.82 | HDAC8 (0.39) | NOTUM | |
| Toluene SCHEMBL10663158 | 0.82 | LMNA (0.48) | NOTUMALDH1A1TSHRNPC1RAB9A | |
| Chlorobenzene SCHEMBL10661939 | 0.82 | TSHR (0.48) | NOTUMCYP19A1TSHRNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109071961-B | Ultra-bright dimeric or polymeric dyes | 索尼公司 | 2021-04-27 | — | — | CN | claimed |
| CN-102329440-B | High-toughness rat-proof poultry egg conveying egg push rod mixture material and preparation method thereof | DUAN HUIZHEN | 2013-03-20 | — | — | CN | claimed |
| CN-102329440-A | High-toughness rat-proof poultry egg conveying egg push rod mixture material and preparation method thereof | YU WANG | 2012-01-25 | — | — | CN | claimed |
| US-7977363-B2 | Fungicides/bactericides for plant protection; exhibit a strong fortifying effect in plants; for controlling cereal diseases against Puccinia species, and diseases in viticulture and fruit and vegetable production against Botrytis, Venturia or Alternaria species; low toxicity; tolrerance | BAYER CROPSCIENCE AG (DE) | 2011-07-12 | — | — | US | claimed |
| CN-114981451-A | Nucleotide probe | 索尼集团公司 | 2022-08-30 | — | — | CN | disclosed |
| CN-109071961-B | Ultra-bright dimeric or polymeric dyes | 索尼公司 | 2021-04-27 | — | — | CN | disclosed |
| US-20200399264-A1 | 4-SUBSTITUTED-2-THIAZOLE AMIDES AS ANTIVIRAL AGENTS | NATIONAL INSTITUTES OF HEALTH | 2020-12-24 | — | — | US | disclosed |
| US-7977363-B2 | Fungicides/bactericides for plant protection; exhibit a strong fortifying effect in plants; for controlling cereal diseases against Puccinia species, and diseases in viticulture and fruit and vegetable production against Botrytis, Venturia or Alternaria species; low toxicity; tolrerance | BAYER CROPSCIENCE AG (DE) | 2011-07-12 | — | — | US | disclosed |
| CN-102002044-A | Purine-8-ketone and thiazolopyrimidine derivatives, and preparation method and medicinal application thereof | UNIV CHINA PHARMA | 2011-04-06 | — | — | CN | disclosed |
| US-20090105316-A1 | Biphenyl Thiazole Carboxamides | BAYER CROPSCIENCE AG (DE) | 2009-04-23 | — | — | US | disclosed |
| US-20090105316-A1 | Biphenyl Thiazole Carboxamides | BAYER CROPSCIENCE AG (DE) | 2009-04-23 | — | — | US | disclosed |
| EP-1981837-A2 | METHODS AND COMPOSITIONS FOR MODULATING SPHINGOSINE-1-PHOSPHATE (S1P) RECEPTOR ACTIVITY | Praecis Pharmaceuticals Incorporated (US) | 2008-10-22 | — | — | EP | disclosed |
| WO-2006020951-A1 | METHODS AND COMPOSITIONS FOR MODULATING SPHINGOSINE-1-PHOSPHATE (S1P) RECEPTOR ACTIVITY | PRAECIS PHARMACEUTICALS, INC. (US) | 2006-02-23 | — | — | WO | disclosed |
| CN-1167692-C | Aminothiazole derivatives and their use as CRF receptor ligands | ʥŵ��-�ϳ�ʵ���ҹ�˾ | 2004-09-22 | — | — | CN | disclosed |
| CN-1370154-A | Aminothiazole derivatives and their use as CRF receptor ligands | SANOFI SYNTHELABO (FR) | 2002-09-18 | — | — | CN | disclosed |
| CN-1058964-C | Branched-amino-sbustituted thiazoles, processes for their preparation and the pharmaceutical compositions which contain them | SANOFI SA (FR) | 2000-11-29 | — | — | CN | disclosed |
| CN-1188476-A | 4-phenylaminothiazole derivatives, method for preparing same, and pharmaceutical compositions thereof | SANOFI SA (FR) | 1998-07-22 | — | — | CN | disclosed |
| US-5665724-A | Substituted pyrimidinylaminothiazole derivatives useful as platelet aggregation inhibitors | ORTHO PHARMACEUTICAL CORPORATION (US) | 1997-09-09 | — | — | US | disclosed |
| US-5530000-A | Substituted pyrimidinylaminothiazole derivatives useful as platelet aggreggation inhibitors | ORTHO PHARMACEUTICAL CORPORATION (US) | 1996-06-25 | — | — | US | disclosed |
| US-5342851-A | Useful in methods of treating reperfusion thrombosis injury | MCNEIL-PPC, INC. (US) | 1994-08-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200399264-A1 | 4-SUBSTITUTED-2-THIAZOLE AMIDES AS ANTIVIRAL AGENTS | MAVS, ZC3HAV1, EIF2AK2 | NOTUM 3909/4885CYP2A6 2504/4885CYP2B6 2723/4885 |
| US-20090105316-A1 | Biphenyl Thiazole Carboxamides | MRPL21, CBR3, BRD4 | NOTUM 1063/4885CYP2A6 433/4885CYP2B6 84/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.