Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AOC3 | Q16853 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2196089 | 0.84 | AOC3 (0.42) | AOC3ALDH1A1ALOX5KDM4EMEN1 | |
| SCHEMBL2197829 | 0.81 | MTOR (0.31) | AOC3MTORALOX5 | |
| SCHEMBL2429212 | 0.79 | ESR1 (0.42) | ALDH1A1HSD17B10ALOX5 | |
| SCHEMBL1448846 | 0.79 | ESR1 (0.42) | ALDH1A1HSD17B10ALOX5 | |
| SCHEMBL2197629 | 0.78 | KDM4E (0.43) | AOC3ALDH1A1HSD17B10KDM4EMEN1 | |
| SCHEMBL1270470 | 0.78 | ALOX5 (0.51) | ALDH1A1ALOX5MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL2197076 | 0.78 | ALOX5 (0.51) | ALDH1A1ALOX5MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL2576026 | 0.78 | ALOX5 (0.51) | ALDH1A1ALOX5MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL2195384 | 0.77 | RIPK1 (0.37) | AOC3TSHRALOX5KDM4EMEN1 | |
| SCHEMBL2197771 | 0.77 | PTGS2 (0.38) | ALDH1A1TSHRALOX5KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7977336-B2 | Aminopyrimidine derivatives as PLK1 inhibitors | BANYU PHARMACEUTICAL CO. LTD (JP) | 2011-07-12 | — | — | US | disclosed |