Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCZ | Q05513 | 2/20 | 0.55 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.54 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.52 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.52 |
| ▸ | CHUK | O15111 | 1/20 | 0.47 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
| ▸ | PRKACA | P17612 | 1/20 | 0.47 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.47 |
| ▸ | AKT1 | P31749 | 1/20 | 0.47 |
| ▸ | CLK2 | P49760 | 1/20 | 0.47 |
| ▸ | PRKX | P51817 | 1/20 | 0.47 |
| ▸ | PRKG2 | Q13237 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.47 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.47 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21999104 | 0.91 | ROCK1 (0.65) | PRKCZROCK1ROCK2KCNH2CHRNB2 | |
| SCHEMBL21999270 | 0.91 | ROCK1 (0.62) | PRKCZROCK1ROCK2KCNH2CHRNB2 | |
| SCHEMBL21999098 | 0.87 | NOS3 (0.50) | PRKCZROCK1ROCK2KCNH2 | |
| SCHEMBL14637040 | 0.82 | NOS3 (0.55) | ROCK1ROCK2KCNH2DYRK1A | |
| SCHEMBL31619927 | 0.82 | NOS3 (0.55) | ROCK1ROCK2KCNH2DYRK1A | |
| SCHEMBL21603259 | 0.82 | PRKCZ (0.55) | PRKCZROCK1ROCK2KCNH2CHRNB2 | |
| SCHEMBL31403631 | 0.79 | NOS3 (0.52) | ROCK1ROCK2KCNH2 | |
| SCHEMBL4007534 | 0.78 | ROCK1 (0.86) | PRKCZROCK1ROCK2KCNH2CHRNB2 | |
| SCHEMBL4003721 | 0.78 | ROCK1 (0.86) | PRKCZROCK1ROCK2KCNH2CHRNB2 | |
| SCHEMBL2266554 | 0.77 | CHRNB2 (0.66) | PRKCZROCK1ROCK2CHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210340105-A1 | AMINOPYRIDINE COMPOUNDS AND METHODS FOR THE PREPARATION AND USE THEREOF | Cortexyme, Inc. (US) | 2021-11-04 | — | — | US | disclosed |
| US-11059786-B2 | Aminopyridine compounds and methods for the preparation and use thereof | Cortexyme, Inc. (US) | 2021-07-13 | — | — | US | disclosed |
| US-20200148642-A1 | AMINOPYRIDINE COMPOUNDS AND METHODS FOR THE PREPARATION AND USE THEREOF | Cortexyme, Inc. (US) | 2020-05-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200148642-A1 | AMINOPYRIDINE COMPOUNDS AND METHODS FOR THE PREPARATION AND USE THEREOF | ENPEP, DNPEP, ANPEP | PRKCZ 979/4885ROCK1 622/4885ROCK2 1002/4885 |
| US-11059786-B2 | Aminopyridine compounds and methods for the preparation and use thereof | ENPEP, DNPEP, ANPEP | PRKCZ 979/4885ROCK1 622/4885ROCK2 1002/4885 |
| US-20210340105-A1 | AMINOPYRIDINE COMPOUNDS AND METHODS FOR THE PREPARATION AND USE THEREOF | ENPEP, DNPEP, ANPEP | PRKCZ 979/4885ROCK1 622/4885ROCK2 1002/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.