Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 2/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.34 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.33 |
| ▸ | COMT | P21964 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | PDE2A | O00408 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10792191 | 0.88 | CYP11B1 (0.39) | CYP11B1CYP11B2KDM4ESMN1; SMN2LMNA | |
| SCHEMBL10795142 | 0.86 | P2RX7 (0.37) | PHF8P2RX7ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL10791998 | 0.84 | CYP11B1 (0.51) | CYP11B1CYP11B2KDM4EL3MBTL1KDM5B | |
| SCHEMBL10791376 | 0.81 | TSHR (0.42) | CYP11B1CYP11B2P2RX7ESR1ESR2 | |
| SCHEMBL11049916 | 0.78 | HPGDS (0.43) | CYP11B1CYP11B2PHF8KDM5BMEN1 | |
| SCHEMBL2200116 | 0.77 | HPGDS (0.40) | CYP11B1CYP11B2PHF8P2RX7KDM5B | |
| SCHEMBL10792639 | 0.76 | ACP1 (0.40) | CYP11B1CYP11B2KDM4EL3MBTL1PHF8 | |
| SCHEMBL10791602 | 0.76 | PHF8 (0.44) | CYP11B1CYP11B2PHF8P2RX7KDM5B | |
| SCHEMBL11045741 | 0.75 | ALDH1A1 (0.35) | P2RX7KDM5BCOMTESR1ESR2 | |
| SCHEMBL10792085 | 0.74 | CYP11B1 (0.47) | CYP11B1CYP11B2KDM4EL3MBTL1PHF8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE32400-E | Substituted imidazole derivatives and their use as anti-thrombosis agents | FARMOS YHTYMA OY (FI) | 1987-04-14 | — | — | US | disclosed |
| US-4514412-A | HYPOTENSIVES, BETA BLOCKERS | FARMOS YHTYMA OY (FI) | 1985-04-30 | — | — | US | disclosed |
| EP-0058047-B1 | SUBSTITUTED IMIDAZOLE DERIVATIVES AND THEIR PREPARATION AND USE | Farmos-Yhtyma Oy (FI) | 1984-11-07 | — | — | EP | disclosed |