Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 8/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22001366 | 0.85 | ALDH1A1 (0.48) | ALDH1A1HTTSMN1; SMN2SOS1KMT2A | |
| SCHEMBL22001748 | 0.84 | ALDH1A1 (0.49) | ALDH1A1HTTSMN1; SMN2SOS1KMT2A | |
| SCHEMBL21043124 | 0.80 | GRK2 (0.42) | ALDH1A1HTTSMN1; SMN2P2RX7LMNA | |
| SCHEMBL21042787 | 0.80 | ALDH1A1 (0.45) | ALDH1A1HTTSMN1; SMN2SOS1KMT2A | |
| SCHEMBL21043082 | 0.79 | L3MBTL1 (0.42) | ALDH1A1SMN1; SMN2KMT2AKDM4EMAPT | |
| SCHEMBL21042583 | 0.75 | SMN1; SMN2 (0.44) | ALDH1A1HTTSMN1; SMN2KMT2AMAPT | |
| SCHEMBL21042783 | 0.75 | ALDH1A1 (0.64) | ALDH1A1HTTSMN1; SMN2KMT2AMAPT | |
| SCHEMBL21042784 | 0.74 | ALDH1A1 (0.52) | ALDH1A1HTTSMN1; SMN2SOS1KMT2A | |
| SCHEMBL22001367 | 0.71 | SMN1; SMN2 (0.36) | ALDH1A1HTTSMN1; SMN2KMT2ALMNA | |
| SCHEMBL16593268 | 0.69 | CHRM1 (0.64) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3489237-B1 | 4-AZAINDOLE DERIVATIVES | EISAI R&D MAN CO LTD (JP) | 2020-05-13 | — | — | EP | disclosed |