Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CCR1 | P32246 | 1/20 | 0.31 |
| ▸ | CCR5 | P51681 | 1/20 | 0.31 |
| ▸ | CCR8 | P51685 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21043468 | 0.86 | CCR1 (0.31) | CCR1CCR5CCR8 | |
| SCHEMBL22001748 | 0.85 | ALDH1A1 (0.49) | SMN1; SMN2ALDH1A1HTTLMNAKMT2A | |
| SCHEMBL21043472 | 0.80 | NR3C1 (0.38) | SMN1; SMN2ALDH1A1POLB | |
| SCHEMBL21043049 | 0.76 | ALDH1A1 (0.42) | SMN1; SMN2ALDH1A1HTTLMNAKMT2A | |
| SCHEMBL22001173 | 0.76 | BRD4 (0.44) | SMN1; SMN2ALDH1A1HTTKMT2AMEN1 | |
| SCHEMBL22001366 | 0.72 | ALDH1A1 (0.48) | SMN1; SMN2ALDH1A1HTTLMNAKMT2A | |
| SCHEMBL22001371 | 0.71 | ALDH1A1 (0.46) | SMN1; SMN2ALDH1A1HTTLMNAKMT2A | |
| SCHEMBL16628258 | 0.70 | CHRM1 (0.32) | — | |
| SCHEMBL16593218 | 0.70 | CHRM1 (0.53) | — | |
| SCHEMBL21042787 | 0.70 | ALDH1A1 (0.45) | SMN1; SMN2ALDH1A1HTTLMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3489237-B1 | 4-AZAINDOLE DERIVATIVES | EISAI R&D MAN CO LTD (JP) | 2020-05-13 | — | — | EP | disclosed |