Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 8/20 | 0.51 |
| ▸ | NPC1 | O15118 | 7/20 | 0.51 |
| ▸ | POLB | P06746 | 5/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 9/20 | 0.49 |
| ▸ | GAA | P10253 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.47 |
| ▸ | MECP2 | P51608 | 3/20 | 0.46 |
| ▸ | MBD2 | Q9UBB5 | 3/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8067145 | 0.61 | HTR7 (0.55) | LMNAALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL24268250 | 0.59 | TSHR (0.42) | POLBMEN1KMT2AMAPTGAA | |
| SCHEMBL16966255 | 0.58 | ALDH1A1 (0.53) | RAB9ANPC1MEN1KMT2AMAPT | |
| SCHEMBL12800015 | 0.58 | POLB (0.51) | POLBKMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL8066265 | 0.58 | HTR1A (0.46) | KMT2AMAPTLMNAALDH1A1KDM4E | |
| SCHEMBL22548901 | 0.57 | CYP1A1 (0.51) | RAB9ANPC1POLBMEN1KMT2A | |
| SCHEMBL8028328 | 0.57 | PDE4B (0.41) | MAPT | |
| SCHEMBL24138613 | 0.56 | MECP2 (0.53) | RAB9ANPC1POLBMEN1KMT2A | |
| SCHEMBL21992018 | 0.56 | TP53 (0.49) | MEN1KMT2AMAPT | |
| SCHEMBL8031101 | 0.56 | HDAC4 (0.46) | MEN1KMT2AMAPTLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200149112-A1 | AGENTS FOR REVERSING EPIGENETIC SILENCING OF GENES | THE JOHNS HOPKINS UNIVERSITY | 2020-05-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200149112-A1 | AGENTS FOR REVERSING EPIGENETIC SILENCING OF GENES | MECP2, MBD2, GATAD2B | RAB9A 3374/4885NPC1 4094/4885POLB 503/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.