Sugi Predict

Sugi Predict / Compounds / SCHEMBL2200232

SCHEMBL2200232

SCHEMBL2200232

COc1cc2c(O)cc3c(c2cc1O)-c1ccccc1C3(C)C

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PDK2 Q15119 3/20 0.41
▸ PARP1 P09874 2/20 0.40
▸ KMT2A Q03164 3/20 0.38
▸ GAA P10253 2/20 0.38
▸ MEN1 O00255 2/20 0.38
▸ L3MBTL1 Q9Y468 2/20 0.38
▸ EP300 Q09472 1/20 0.37
▸ HPGD P15428 2/20 0.37
▸ PGR P06401 1/20 0.35
▸ AR P10275 1/20 0.35
▸ ALDH1A1 P00352 3/20 0.34
▸ TP53 P04637 2/20 0.34
▸ KDM4E B2RXH2 2/20 0.34
▸ HSD17B10 Q99714 2/20 0.34
▸ CYP2D6 P10635 1/20 0.34
▸ CYP2C19 P33261 1/20 0.34
▸ PTPN1 P18031 2/20 0.34
▸ CA1 P00915 1/20 0.34
▸ CA2 P00918 1/20 0.34
▸ TSHR P16473 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30104202 1.00 PDK2 (0.41) PDK2PARP1KMT2AGAAMEN1
SCHEMBL30125362 0.94 PDK2 (0.40) PDK2PARP1KMT2AGAAMEN1
SCHEMBL165110 0.94 PDK2 (0.40) PDK2PARP1KMT2AGAAMEN1
SCHEMBL16301275 0.87 PDK2 (0.38) PDK2KMT2AGAAMEN1HPGD
SCHEMBL13868700 0.87 TUBB4A (0.40) PDK2PGRAR
SCHEMBL4572109 0.86 PDK2 (0.34) PDK2PARP1KMT2AGAAMEN1
SCHEMBL15247981 0.86 PDK2 (0.34) PDK2PARP1KMT2AGAAMEN1
SCHEMBL23572575 0.85 ALDH1A1 (0.38) PDK2KMT2AMEN1L3MBTL1ALDH1A1
SCHEMBL4568638 0.85 PDK2 (0.34) PDK2PARP1KMT2AGAAMEN1
SCHEMBL30104203 0.85 ALDH1A1 (0.38) PDK2KMT2AMEN1L3MBTL1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 71 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3367143-B1 POLARIZING PHOTOCHROMIC DEVICES AND METHODS OF MAKING THE SAME TRANSITIONS OPTICAL INC (US) 2023-01-11 — — EP disclosed
US-11518751-B2 Photochromic indeno-fused naphthopyran compounds with reduced temperature dependence TRANSITIONS OPTICAL, LTD. (IE) 2022-12-06 — — US disclosed
EP-3802508-B1 PHOTOCHROMIC INDENO-FUSED NAPHTHOPYRAN COMPOUNDS WITH REDUCED TEMPERATURE DEPENDENCE TRANSITIONS OPTICAL LTD (IE) 2022-10-19 — — EP disclosed
US-20210198226-A1 Photochromic Indeno-Fused Naphthopyran Compounds With Reduced Temperature Dependence TRANSITIONS OPTICAL, LTD. (IE) 2021-07-01 — — US disclosed
CN-105199708-B Photochromic compounds 光学转变公司 2020-10-27 — — CN disclosed
EP-1639058-B1 PHOTOCHROMIC COMPOUNDS TRANSITIONS OPTICAL INC (US) 2020-10-21 — — EP disclosed
CN-105838349-B photochromic compounds 光学转变公司 2019-12-06 — — CN disclosed
EP-2370420-B9 PHOTOCHROMIC COMPOUNDS TRANSITIONS OPTICAL INC (US) 2019-11-13 — — EP disclosed
EP-2370420-B1 PHOTOCHROMIC COMPOUNDS TRANSITIONS OPTICAL INC (US) 2019-05-22 — — EP disclosed
EP-2357217-B9 PHOTOCHROMIC COMPOUNDS TRANSITIONS OPTICAL INC (US) 2019-03-13 — — EP disclosed
US-20070047055-A1 Polarizing, photochromic devices and methods of making the same TRANSITIONS OPTICAL LIMITED (IE) 2007-03-01 — — US disclosed
US-20070047054-A1 Polarizing, photochromic devices and methods of making the same TRANSITIONS OPTICAL LIMITED (IE) 2007-03-01 — — US disclosed
US-20070041073-A1 Polarizing, photochromic devices and methods of making the same TRANSITIONS OPTICAL LIMITED (IE) 2007-02-22 — — US disclosed
US-20070041071-A1 Polarizing, photochromic devices and methods of making the same TRANSITIONS OPTICAL LIMITED (IE) 2007-02-22 — — US disclosed
EP-1642160-A1 POLARIZING PHOTOCHROMIC DEVICES AND METHODS OF MAKING THE SAME TRANSITIONS OPTICAL, INC. (US) 2006-04-05 — — EP disclosed
EP-1639058-A1 PHOTOCHROMIC COMPOUNDS TRANSITIONS OPTICAL, INC. (US) 2006-03-29 — — EP disclosed
WO-2005005570-A1 PHOTOCHROMIC COMPOUNDS TRANSITIONS OPTICAL, INC. (US) 2005-01-20 — — WO disclosed
WO-2005006035-A1 POLARIZING PHOTOCHROMIC DEVICES AND METHODS OF MAKING THE SAME TRANSITIONS OPTICAL, INC. (US) 2005-01-20 — — WO disclosed
US-20050012998-A1 Polarizing, photochromic devices and methods of making the same TRANSITIONS OPTICAL LIMITED (IE) 2005-01-20 — — US disclosed
US-20050004361-A1 Thermally reversible; absorption ratio greater than 2.3 TRANSITIONS OPTICAL LIMITED (IE) 2005-01-06 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210198226-A1 Photochromic Indeno-Fused Naphthopyran Compounds With Reduced Temperature Dependence NR2E3, NR0B2, NR2C2 PDK2 745/4885PARP1 2662/4885KMT2A 1967/4885
US-20050004361-A1 Thermally reversible; absorption ratio greater than 2.3 CCND1, CCND3, CCND2 PDK2 501/4885PARP1 1854/4885KMT2A 1838/4885
US-11518751-B2 Photochromic indeno-fused naphthopyran compounds with reduced temperature dependence NR2E3, NR0B2, NR2C2 PDK2 745/4885PARP1 2662/4885KMT2A 1967/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.