Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.37 |
| ▸ | CDK4 | P11802 | 2/20 | 0.37 |
| ▸ | CCND1 | P24385 | 2/20 | 0.37 |
| ▸ | FYN | P06241 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | CCND3 | P30281 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 3/20 | 0.36 |
| ▸ | ABCC1 | P33527 | 4/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30104203 | 1.00 | ALDH1A1 (0.38) | ALDH1A1KDM4ETP53CYP2D6CYP2C19 | |
| SCHEMBL1010811 | 0.95 | EGFR (0.38) | CHEK1CDK4CCND1FYNFGFR1 | |
| SCHEMBL164197 | 0.95 | EGFR (0.38) | CHEK1CDK4CCND1FYNFGFR1 | |
| SCHEMBL2200232 | 0.85 | PDK2 (0.41) | ALDH1A1KDM4ETP53CYP2D6CYP2C19 | |
| SCHEMBL30104202 | 0.85 | PDK2 (0.41) | ALDH1A1KDM4ETP53CYP2D6CYP2C19 | |
| SCHEMBL1012466 | 0.85 | FYN (0.37) | ALDH1A1KDM4ECYP2D6CYP2C19FYN | |
| SCHEMBL30125488 | 0.85 | PDK2 (0.47) | ALDH1A1KDM4ECYP2D6CYP2C19HSD17B10 | |
| SCHEMBL8513816 | 0.85 | PDK2 (0.47) | ALDH1A1KDM4ECYP2D6CYP2C19HSD17B10 | |
| SCHEMBL1816275 | 0.85 | KDM4E (0.36) | ALDH1A1KDM4EHSD17B10MEN1POLB | |
| SCHEMBL1010936 | 0.84 | RARA (0.48) | EGFRMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11518751-B2 | Photochromic indeno-fused naphthopyran compounds with reduced temperature dependence | TRANSITIONS OPTICAL, LTD. (IE) | 2022-12-06 | — | — | US | disclosed |
| EP-3802508-B1 | PHOTOCHROMIC INDENO-FUSED NAPHTHOPYRAN COMPOUNDS WITH REDUCED TEMPERATURE DEPENDENCE | TRANSITIONS OPTICAL LTD (IE) | 2022-10-19 | — | — | EP | disclosed |
| US-20210198226-A1 | Photochromic Indeno-Fused Naphthopyran Compounds With Reduced Temperature Dependence | TRANSITIONS OPTICAL, LTD. (IE) | 2021-07-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210198226-A1 | Photochromic Indeno-Fused Naphthopyran Compounds With Reduced Temperature Dependence | NR2E3, NR0B2, NR2C2 | ALDH1A1 1149/4885KDM4E 4170/4885TP53 2427/4885 |
| US-11518751-B2 | Photochromic indeno-fused naphthopyran compounds with reduced temperature dependence | NR2E3, NR0B2, NR2C2 | ALDH1A1 1149/4885KDM4E 4170/4885TP53 2427/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.